公开(公告)号：US10851063B2

公开(公告)日：2020-12-01

申请号：US16151798

申请日：2018-10-04

申请人： AMPAC Fine Chemicals LLC

发明人： William Dubay ,  Alex Nichols ,  Wei Chen ,  Alec Brozell ,  Ajay Ryerson

IPC分类号： C07D221/28 ,  C07C59/255

摘要： A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.

公开(公告)号：US09090539B2

公开(公告)日：2015-07-28

申请号：US13902296

申请日：2013-05-24

申请人： AMPAC Fine Chemicals LLC

发明人： Brian Morgan ,  Olivier Dapremont ,  Patrick Berget ,  Ali Suleman ,  William Dubay ,  Jeffrey D. Butler

IPC分类号： C07C253/30 ,  C07C255/36 ,  C07C255/37 ,  C07C213/02 ,  C07C215/54

CPC分类号： C07C253/30 ,  C07B2200/07 ,  C07B2200/09 ,  C07C213/02 ,  C07C215/54 ,  C07C255/36 ,  C07C255/37

摘要： Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds from an isomerically pure starting material are described. In particular, methods of preparing a 3-(1-(dimethylamino)-2-methylpentane-3-yl)phenol as a substantially optically pure (R,R) stereoisomer are described. Using a method of the present invention, only the (R,R) and (S,S) stereoisomers of the target compound are produced, increasing the yield and stereoselectivity of the desired (R,R) stereoisomer.

摘要翻译： 描述了由异构纯的起始原料制备取代的3-（1-氨基-2-甲基戊烷-3-基）苯基化合物的化合物和方法。 特别地，描述了制备作为基本上光学纯的（R，R）立体异构体的3-（1-（二甲基氨基）-2-甲基戊烷-3-基）苯酚的方法。 使用本发明的方法，仅产生目标化合物的（R，R）和（S，S）立体异构体，从而提高所需（R，R）立体异构体的产率和立体选择性。