公开(公告)号：US20240301042A1

公开(公告)日：2024-09-12

申请号：US18283697

申请日：2022-03-23

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Ping HE ,  Michael SIERKS

IPC: C07K16/18 ,  A61K39/00 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61P25/28 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/74 ,  C07K2319/10

Abstract: The invention provides methods and compositions for treating or ameliorating Alzheimer's disease. The invention provides agents that reduce Aβ inclusions and plaque accumulation, inhibit dendrite spine loss, and restore neurogenesis.