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公开(公告)号：US20200278358A1
公开(公告)日：2020-09-03
申请号：US16588481
申请日：2019-09-30
Inventor： Michael SIERKS , Stephanie WILLIAMS
IPC: G01N33/68
Abstract: The invention provides diagnostic tests to distinguish between different pre-symptomatic neurodegenerative diseases.
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公开(公告)号：US20190195892A1
公开(公告)日：2019-06-27
申请号：US16121481
申请日：2018-09-04
Inventor： Michael SIERKS , Stephanie WILLIAMS
IPC: G01N33/68
CPC classification number: G01N33/6896 , G01N2333/005 , G01N2333/4709 , G01N2800/28 , G01N2800/2821 , G01N2800/2835 , G01N2800/50
Abstract: The invention provides diagnostic tests to distinguish between different pre-symptomatic neurodegenerative diseases.
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3.发明公开公开(公告)号：US20230220401A1
公开(公告)日：2023-07-13
申请号：US18085418
申请日：2022-12-20
Inventor： Michael SIERKS , Lalitha VENKATARAMAN , Wei XIN
CPC classification number: C12N15/62 , G01N33/6896 , C07K16/18 , C07K1/22 , A61P25/28 , G01N2800/2821
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.
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4.发明申请公开(公告)号：US20190250171A1
公开(公告)日：2019-08-15
申请号：US16211006
申请日：2018-12-05
Inventor： Michael SIERKS , Stephanie WILLIAMS , Lalitha VENKATARAMAN
CPC classification number: G01N33/6896 , C07K16/18 , C07K2317/622 , G01N2800/2814 , G01N2800/285
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.
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公开(公告)号：US20220221795A1
公开(公告)日：2022-07-14
申请号：US17499777
申请日：2021-10-12
Inventor： Michael SIERKS , Stephanie WILLIAMS
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI), assessment of the amount of neuronal damage, and/or susceptibility to neurodegenerative disease in a subject.
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Patent Agency Ranking
公开(公告)号：US20200299367A1
公开(公告)日：2020-09-24
申请号：US16672034
申请日：2019-11-01
Inventor： Michael SIERKS , Huilai TIAN
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
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7.发明申请ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE NEURODEGENERATIVE DISEASE RELATED FORMS OF THE PROTEIN TDP-43 审中-公开抗体基因型特异性识别蛋白TDP-43相关表型的神经细胞病公开(公告)号：US20170010284A1
公开(公告)日：2017-01-12
申请号：US15114356
申请日：2015-02-02
Inventor： Michael SIERKS , Stephanie WILLIAMS , Lalitha VENKATARAMAN
CPC classification number: G01N33/6896 , C07K16/18 , C07K2317/622 , G01N2800/2814 , G01N2800/285
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with frontotemporal dementia (FTD), but not TDP-43 associated with amyotrophic lateral sclerosis (ALS) or TDP-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize TDP-43 associated with ALS, but not TDP-43 associated FTD or TDP-43 associated with healthy human brain tissue.
Abstract translation: 本发明涉及特异性识别与额颞叶痴呆（FTD）相关的TDP-43但与健康人脑组织相关的肌萎缩性侧索硬化（ALS）或TDP-43相关的TDP-43的抗体，抗体片段和结合剂，以及 抗体，抗体片段和特异性识别与健康人类脑组织相关的与ALS相关的TDP-43而不与TDP-43相关联的FTD或TDP-43的结合剂。
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公开(公告)号：US20240301042A1
公开(公告)日：2024-09-12
申请号：US18283697
申请日：2022-03-23
Inventor： Ping HE , Michael SIERKS
CPC classification number: C07K16/18 , A61P25/28 , A61K2039/505 , C07K2317/622 , C07K2317/74 , C07K2319/10
Abstract: The invention provides methods and compositions for treating or ameliorating Alzheimer's disease. The invention provides agents that reduce Aβ inclusions and plaque accumulation, inhibit dendrite spine loss, and restore neurogenesis.
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9.发明申请公开(公告)号：US20190010504A1
公开(公告)日：2019-01-10
申请号：US16060880
申请日：2016-12-09
Inventor： Michael SIERKS , Lalitha VENKATARAMAN , Wei XIN
Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.
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公开(公告)号：US20170205431A1
公开(公告)日：2017-07-20
申请号：US15479110
申请日：2017-04-04
Inventor： Michael SIERKS , Huilai TIAN
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/30 , C07K2317/62 , C07K2317/622 , C07K2317/76 , C12N15/1037 , G01N33/6896 , G01N2333/47 , G01N2333/4703 , G01N2800/28 , G01N2800/2814 , G01N2800/2821 , G01N2800/7047
Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.
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