公开(公告)号：US20220089455A1

公开(公告)日：2022-03-24

申请号：US17418704

申请日：2019-12-27

申请人： ASTELLAS PHARMA INC.

发明人： Takashi KIKUCHI ,  Tsuyoshi MIZUTANI ,  Hiroki TOYA ,  Akio KURODA ,  Yota GOTO ,  Shun HIRASAWA ,  Toshiyuki SUGIMORI

IPC分类号： C01G49/06 ,  A61K49/18 ,  C01G49/08

摘要： [Problem]
A novel method for producing a nanoparticle having a metal particle which contains iron oxide to which one or more hydrophilic ligands are coordination bonded is provided, where the nanoparticle is useful as a contrast agent for magnetic resonance imaging.
[Means for Solution]
As the novel method for producing a nanoparticle having a metal particle which contains iron oxide to which one or more hydrophilic ligands are coordination bonded, by performing ligand exchange to a hydrophilic ligand from an iron oxide nanoparticle having a surface to which a hydrophobic ligand is coordination bonded in one step using a phase transfer catalyst, it is possible to expect shortening of production processes and reduction of hydrophilic ligands used.
Furthermore, by producing an iron oxide nanoparticle having a surface to which a hydrophobic ligand is coordination bonded using a dropwise addition method, it is possible to avoid a rapid temperature rise and a reaction at a high temperature of 200° C. or higher, which is more advantageous for industrial production.