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公开(公告)号:US20220089455A1
公开(公告)日:2022-03-24
申请号:US17418704
申请日:2019-12-27
申请人: ASTELLAS PHARMA INC.
发明人: Takashi KIKUCHI , Tsuyoshi MIZUTANI , Hiroki TOYA , Akio KURODA , Yota GOTO , Shun HIRASAWA , Toshiyuki SUGIMORI
摘要: [Problem]
A novel method for producing a nanoparticle having a metal particle which contains iron oxide to which one or more hydrophilic ligands are coordination bonded is provided, where the nanoparticle is useful as a contrast agent for magnetic resonance imaging.
[Means for Solution]
As the novel method for producing a nanoparticle having a metal particle which contains iron oxide to which one or more hydrophilic ligands are coordination bonded, by performing ligand exchange to a hydrophilic ligand from an iron oxide nanoparticle having a surface to which a hydrophobic ligand is coordination bonded in one step using a phase transfer catalyst, it is possible to expect shortening of production processes and reduction of hydrophilic ligands used.
Furthermore, by producing an iron oxide nanoparticle having a surface to which a hydrophobic ligand is coordination bonded using a dropwise addition method, it is possible to avoid a rapid temperature rise and a reaction at a high temperature of 200° C. or higher, which is more advantageous for industrial production.