公开(公告)号：US10668167B2

公开(公告)日：2020-06-02

申请号：US16408602

申请日：2019-05-10

Applicant: AbbVie Inc.

Inventor： Michael J. McPherson ,  Adrian D. Hobson ,  Martin E. Hayes ,  Christopher C. Marvin ,  Diana Schmidt ,  Wendy Waegell ,  Christian Goess ,  Jason Z. Oh ,  Axel Hernandez, Jr. ,  John T. Randolph

IPC: A61K47/68 ,  C07K16/24 ,  A61P37/06 ,  C07J71/00 ,  A61K39/00 ,  C07K16/18

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.

公开(公告)号：US20220354959A1

公开(公告)日：2022-11-10

申请号：US17318723

申请日：2021-05-12

Applicant: AbbVie Inc.

Inventor： Michael J. McPherson ,  Adrian D. Hobson ,  Martin E. Hayes ,  Christopher C. Marvin ,  Diana Schmidt ,  Wendy Waegell ,  Christian Goess ,  Jason Z. Oh ,  Axel Hernandez, Jr. ,  John T. Randolph

IPC: A61K47/68 ,  C07K16/24 ,  A61P37/06 ,  C07J71/00

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.

公开(公告)号：US20220265842A1

公开(公告)日：2022-08-25

申请号：US16768616

申请日：2018-11-29

Applicant: AbbVie Inc.

Inventor： Adrian D. Hobson ,  Jason Z. Oh ,  Michael J. McPherson ,  Wendy Waegell ,  Shaughn H. Bryant ,  Axel Hernandez, Jr. ,  Claire L. Ihle ,  Christopher C. Marvin ,  Olivia A. Perng ,  Ling C. Santora ,  Lu Wang ,  Lu Wang

IPC: A61K47/68 ,  A61P37/00 ,  C07K16/28

Abstract: Provided herein are anti-CD40 antibody drug conjugates comprising a radical of Formula (I), wherein R1, R2, and R3 are as defined herein. Further provided are anti-CD40 antibody drug conjugates of Formula (II), wherein Z, R, AA1, AA2, AA3, m, p, q, n, w, R1, R2, and R3 are as defined herein. Further provided are pharmaceutical compositions and kits thereof, and methods of using same.

公开(公告)号：US20200338208A1

公开(公告)日：2020-10-29

申请号：US16850866

申请日：2020-04-16

Applicant: AbbVie Inc.

Inventor： Michael J. McPherson ,  Adrian D. Hobson ,  Martin E. Hayes ,  Christopher C. Marvin ,  Diana Schmidt ,  Wendy Waegell ,  Christian Goess ,  Jason Z. Oh ,  Axel Hernandez, JR. ,  John T. Randolph

IPC: A61K47/68 ,  C07K16/24 ,  A61P37/06 ,  C07J71/00

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.