公开(公告)号：US10772970B2

公开(公告)日：2020-09-15

申请号：US16204825

申请日：2018-11-29

Applicant: AbbVie Inc.

Inventor： Adrian Hobson ,  Michael McPherson ,  Wendy Waegell ,  Christian Goess ,  Axel Hernandez, Jr. ,  Lu Wang ,  Lu Wang ,  Christopher C. Marvin ,  Ling C. Santora

IPC: A61K47/68 ,  A61P19/02 ,  A61P1/00 ,  A61K38/19 ,  C07K16/24

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.

公开(公告)号：US20220265842A1

公开(公告)日：2022-08-25

申请号：US16768616

申请日：2018-11-29

Applicant: AbbVie Inc.

Inventor： Adrian D. Hobson ,  Jason Z. Oh ,  Michael J. McPherson ,  Wendy Waegell ,  Shaughn H. Bryant ,  Axel Hernandez, Jr. ,  Claire L. Ihle ,  Christopher C. Marvin ,  Olivia A. Perng ,  Ling C. Santora ,  Lu Wang ,  Lu Wang

IPC: A61K47/68 ,  A61P37/00 ,  C07K16/28

Abstract: Provided herein are anti-CD40 antibody drug conjugates comprising a radical of Formula (I), wherein R1, R2, and R3 are as defined herein. Further provided are anti-CD40 antibody drug conjugates of Formula (II), wherein Z, R, AA1, AA2, AA3, m, p, q, n, w, R1, R2, and R3 are as defined herein. Further provided are pharmaceutical compositions and kits thereof, and methods of using same.

公开(公告)号：US20210015938A1

公开(公告)日：2021-01-21

申请号：US16945069

申请日：2020-07-31

Applicant: AbbVie Inc.

Inventor： Adrian D. Hobson ,  Michael J. McPherson ,  Wendy Waegell ,  Christian Goess ,  Axel Hernandez, Jr. ,  Lu Wang ,  Lu Wang ,  Christopher C. Marvin ,  Ling C. Santora

IPC: A61K47/68 ,  A61P19/02 ,  A61P1/00 ,  A61K38/19 ,  C07K16/24

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same.

公开(公告)号：US10668167B2

公开(公告)日：2020-06-02

申请号：US16408602

申请日：2019-05-10

Applicant: AbbVie Inc.

Inventor： Michael J. McPherson ,  Adrian D. Hobson ,  Martin E. Hayes ,  Christopher C. Marvin ,  Diana Schmidt ,  Wendy Waegell ,  Christian Goess ,  Jason Z. Oh ,  Axel Hernandez, Jr. ,  John T. Randolph

IPC: A61K47/68 ,  C07K16/24 ,  A61P37/06 ,  C07J71/00 ,  A61K39/00 ,  C07K16/18

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.

公开(公告)号：US11639390B2

公开(公告)日：2023-05-02

申请号：US17378565

申请日：2021-07-16

Applicant: AbbVie Inc.

Inventor： Jing Min ,  Teresa (Iok-Chan) Ng ,  Lorenzo Benatuil ,  Jacqueline Bixby ,  Tatyana Dekhtyar ,  Feng Dong ,  Axel Hernandez, Jr. ,  Preethi Krishnan ,  Liangjun Lu ,  Federico Mensa ,  Renee Miller ,  Gautam Sahu

IPC: C12N5/02 ,  C12N5/20 ,  C12N1/20 ,  C12N15/00 ,  C07K16/46 ,  C07K16/00 ,  C07H21/04 ,  C07K16/28 ,  A61P31/18 ,  C12N15/63 ,  A61K39/00

Abstract: The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.

公开(公告)号：US20220354959A1

公开(公告)日：2022-11-10

申请号：US17318723

申请日：2021-05-12

Applicant: AbbVie Inc.

Inventor： Michael J. McPherson ,  Adrian D. Hobson ,  Martin E. Hayes ,  Christopher C. Marvin ,  Diana Schmidt ,  Wendy Waegell ,  Christian Goess ,  Jason Z. Oh ,  Axel Hernandez, Jr. ,  John T. Randolph

IPC: A61K47/68 ,  C07K16/24 ,  A61P37/06 ,  C07J71/00

Abstract: Provided herein are glucocorticoid receptor agonist immunoconjugates, glucocorticoid receptor agonists, and methods of using the same, e.g., to treat autoimmune or inflammatory diseases.

公开(公告)号：US20220017624A1

公开(公告)日：2022-01-20

申请号：US17378565

申请日：2021-07-16

Applicant: AbbVie Inc.

Inventor： Jing Min ,  Teresa (Iok-Chan) Ng ,  Lorenzo Benatuil ,  Jacqueline Bixby ,  Tatyana Dekhtyar ,  Feng Dong ,  Axel Hernandez, Jr. ,  Preethi Krishnan ,  Liangjun Lu ,  Federico Mensa ,  Renee Miller ,  Gautam Sahu

IPC: C07K16/28 ,  A61P31/18 ,  C12N15/63

Abstract: The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.