公开(公告)号：US20160319010A1

公开(公告)日：2016-11-03

申请号：US15198696

申请日：2016-06-30

Applicant: AbbVie Inc.

Inventor： Boris Labkovsky ,  Tariq Ghayur ,  Georgeen Gaza-Bulseco ,  Pratibha Mishra ,  Subramanya Hegde ,  Sudha Krishnan

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/77 ,  Y02A50/386

Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.

公开(公告)号：US20170306010A1

公开(公告)日：2017-10-26

申请号：US15641508

申请日：2017-07-05

Applicant: AbbVie Inc.

Inventor： Boris Labkovsky ,  Tariq Ghayur ,  Georgeen Gaza-Bulseco ,  Pratibha Mishra ,  Subramanya Hegde ,  Sudha Krishnan

IPC: C07K16/24 ,  C07K16/00 ,  A61K39/00

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/77 ,  Y02A50/386

Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.

公开(公告)号：US09550826B2

公开(公告)日：2017-01-24

申请号：US15198696

申请日：2016-06-30

Applicant: AbbVie Inc.

Inventor： Boris Labkovsky ,  Tariq Ghayur ,  Georgeen Gaza-Bulseco ,  Pratibha Mishra ,  Subramanya Hegde ,  Sudha Krishnan

IPC: C07K16/24 ,  A61K39/00

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/77 ,  Y02A50/386

Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.

Abstract translation: 提供具有减少的抗药物免疫应答（ADA）的具有Fc结构域的结合蛋白的糖工程化群体。 还提供了使用这种组合物治疗疾病的方法，以及制备这种组合物的方法和宿主。

公开(公告)号：US20180298093A1

公开(公告)日：2018-10-18

申请号：US15912494

申请日：2018-03-05

Applicant: AbbVie Inc.

Inventor： Boris Labkovsky ,  Tariq Ghayur ,  Georgeen Gaza-Bulseco ,  Pratibha Mishra ,  Subramanya Hegde ,  Sudha Krishnan

IPC: C07K16/24 ,  C07K16/00

Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.

公开(公告)号：US20150139988A1

公开(公告)日：2015-05-21

申请号：US14542281

申请日：2014-11-14

Applicant: AbbVie, Inc.

Inventor： Boris Labkovsky ,  Tariq Ghayur ,  Georgeen Gaza-Bulseco ,  Pratibha Mishra ,  Subramanya Hedge ,  Sudha Krishnan

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/77 ,  Y02A50/386

Abstract: Provided are glycoengineered populations of Fc domain-containing binding proteins with a reduced anti-drug immune response (ADA). Also provided are methods of treating disease using such compositions, and methods and host for making such compositions.

Abstract translation: 提供具有减少的抗药物免疫应答（ADA）的具有Fc结构域的结合蛋白的糖工程化群体。 还提供了使用这种组合物治疗疾病的方法，以及制备这种组合物的方法和宿主。