公开(公告)号：US20160031986A1

公开(公告)日：2016-02-04

申请号：US14798849

申请日：2015-07-14

Applicant: AbbVie Inc.

Inventor： Ming-Jiu CHEN ,  Chung-Ming HSIEH ,  Jijie GU ,  Susan E. MORGAN-LAPPE ,  Yingchun LI

IPC: C07K16/28 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/28 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

Abstract translation: 本文描述了DLL4结合蛋白，包括抗体，CDR-移植抗体，人源化抗体及其DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4和/或VEGF活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成。