公开(公告)号：US11339405B2

公开(公告)日：2022-05-24

申请号：US15951114

申请日：2018-04-11

Applicant: Academia Sinica

Inventor： Hung-Chih Kuo ,  Ching-Yu Chuang ,  Chan-Hsien Yeh

IPC: C12N15/85 ,  G01N33/50 ,  C12N5/079 ,  A61K35/36 ,  C12N5/09 ,  C12N5/0793 ,  C12N5/0797 ,  A61K35/30 ,  C12N15/86 ,  C12N5/077

Abstract: Disclosed herein are kits comprising transcription factors for inducing a fibroblast cell into an induced embryonic neural progenitor cell. The induced embryonic neural progenitor cell is then capable of differentiating into an astrocyte, an oligodendrocyte or a neuron. Also disclosed are the uses of the kit as a platform for selecting a drug candidate to treat neurological diseases.