Indane derivatives for treating endotoxin shock and/or nephritis
    2.
    发明授权
    Indane derivatives for treating endotoxin shock and/or nephritis 失效
    用于治疗内毒素休克和/或肾炎的吲哚衍生物

    公开(公告)号:US5543409A

    公开(公告)日:1996-08-06

    申请号:US445202

    申请日:1995-05-23

    摘要: Disclosed are indane compounds represented by the formula: ##STR1## wherein R.sup.1 is aryl, lower alkyl, cycloalkyl, halogeno-lower alkyl, lower alkenyl, phenyl-substituted lower alkenyl, monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, lower alkoxy, phenoxy, lower alkylamino, lower alkenylamino, phenylamino, lower alkyl substituted by monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, or lower alkenyloxy; R.sup.2 is H or lower alkyl; X is carbonyl or thiocarbonyl; Alk is single bonding arm or lower alkylene; and the dotted line is presence or absence of a double bond, for treating endotoxin shock and/or nephritis.

    摘要翻译: 公开了由下式表示的茚满化合物:其中R 1是芳基,低级烷基,环烷基,卤代低级烷基,低级烯基,苯基取代的低级烯基,具有N,O或S的单环或双环芳族杂环 作为杂原子,低级烷氧基,苯氧基,低级烷基氨基,低级链烯基氨基,苯基氨基,被具有N,O或S作为杂原子的单环或双环芳族杂环取代的低级烷基,或低级烯氧基; R2是H或低级烷基; X是羰基或硫代羰基; Alk是单键或低级亚烷基; 虚线是双键存在或不存在,用于治疗内毒素休克和/或肾炎。

    Pyridazinone derivatives and processes for preparing the same
    4.
    发明授权
    Pyridazinone derivatives and processes for preparing the same 失效
    哒嗪酮衍生物及其制备方法

    公开(公告)号:US5698554A

    公开(公告)日:1997-12-16

    申请号:US671485

    申请日:1996-06-27

    摘要: Disclosed is a pyridazinone compound represented by the formula (I): ##STR1## wherein X represents hydrogen atom or the like; Y represents a single bonding arm, oxygen atom or sulfur atom; A represents a straight or branched alkylene group which may have a double bond; B represents carbonyl group or thiocarbonyl group; and R.sup.2 represents an alkyl group having 1 to 10 carbon atoms which may be substituted or the like; or B represents sulfonyl group; and R.sup.2 represents a lower alkenyl group or the like; R.sup.1 represents hydrogen atom or the like; R.sup.3 represents hydrogen atom or the like; R.sup.4 represents hydrogen atom or the like; and R.sup.5 represents hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.

    摘要翻译: 公开了由式(I)表示的哒嗪酮化合物:其中X表示氢原子等;(I) Y表示单键键,氧原子或硫原子; A表示可以具有双键的直链或支链亚烷基; B表示羰基或硫代羰基; R 2表示可以具有取代基的碳原子数1〜10的烷基等。 或B表示磺酰基; 并且R 2表示低级烯基等; R1表示氢原子等; R3表示氢原子等; R4代表氢原子等; R5代表氢原子等,或其药学上可接受的盐。