公开(公告)号：US4804672A

公开(公告)日：1989-02-14

申请号：US131355

申请日：1987-12-10

申请人： Isao Yamaguchi ,  Shinsuke Nishiyama ,  Masami Kubo

发明人： Isao Yamaguchi ,  Shinsuke Nishiyama ,  Masami Kubo

IPC分类号： A61K38/04 ,  A61K31/415

CPC分类号： A61K38/04

摘要： Novel agent for the treatment of kidney diseases, which comprises as an active ingredient a 2-oxo-imidazolidine compound of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is a lower alkyl group, R.sup.3 is a phenyl-substituted lower alkyl group, and R.sup.4 is hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US5543409A

公开(公告)日：1996-08-06

申请号：US445202

申请日：1995-05-23

申请人： Akihiko Ishida ,  Koichi Homma ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Koichi Homma ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： C07D237/04 ,  C07D237/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/50

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D237/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed are indane compounds represented by the formula: ##STR1## wherein R.sup.1 is aryl, lower alkyl, cycloalkyl, halogeno-lower alkyl, lower alkenyl, phenyl-substituted lower alkenyl, monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, lower alkoxy, phenoxy, lower alkylamino, lower alkenylamino, phenylamino, lower alkyl substituted by monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, or lower alkenyloxy; R.sup.2 is H or lower alkyl; X is carbonyl or thiocarbonyl; Alk is single bonding arm or lower alkylene; and the dotted line is presence or absence of a double bond, for treating endotoxin shock and/or nephritis.

摘要翻译： 公开了由下式表示的茚满化合物：其中R 1是芳基，低级烷基，环烷基，卤代低级烷基，低级烯基，苯基取代的低级烯基，具有N，O或S的单环或双环芳族杂环 作为杂原子，低级烷氧基，苯氧基，低级烷基氨基，低级链烯基氨基，苯基氨基，被具有N，O或S作为杂原子的单环或双环芳族杂环取代的低级烷基，或低级烯氧基; R2是H或低级烷基; X是羰基或硫代羰基; Alk是单键或低级亚烷基; 虚线是双键存在或不存在，用于治疗内毒素休克和/或肾炎。

公开(公告)号：US5808065A

公开(公告)日：1998-09-15

申请号：US917113

申请日：1997-08-25

申请人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P13/12 ,  C07D237/14 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12 ,  C07D237/30 ,  C07D401/00 ,  C07D403/00 ,  C07D405/00

CPC分类号： C07D401/12 ,  C07D237/14 ,  C07D403/12 ,  C07D409/12

摘要： Disclosed is a pyridazinone compound represented by the formula (I): ##STR1## wherein X represents hydrogen atom or the like; Y represents a single bonding arm, oxygen atom or sulfur atom; A represents a straight or branched alkylene group which may have a double bond; B represents carbonyl group or thiocarbonyl group; and R.sup.2 represents an alkyl group having 1 to 10 carbon atoms which may be substituted or the like; or B represents sulfonyl group; and R.sup.2 represents a lower alkenyl group or the like; R.sup.1 represents hydrogen atom or the like; R.sup.3 represents hydrogen atom or the like; R.sup.4 represents hydrogen atom or the like; and R.sup.5 represents hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了由式（I）表示的哒嗪酮化合物：其中X表示氢原子等;（I） Y表示单键键，氧原子或硫原子; A表示可以具有双键的直链或支链亚烷基; B表示羰基或硫代羰基; R 2表示可以具有取代基的碳原子数1〜10的烷基等。 或B表示磺酰基; 并且R 2表示低级烯基等; R1表示氢原子等; R3表示氢原子等; R4代表氢原子等; R5代表氢原子等，或其药学上可接受的盐。

公开(公告)号：US5686452A

公开(公告)日：1997-11-11

申请号：US767392

申请日：1996-12-16

申请人： Akihiko Ishida ,  Koichi Homma ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Koichi Homma ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： C07D237/14 ,  C07D401/12 ,  A61K31/50

CPC分类号： C07D401/12 ,  C07D237/14

摘要： Disclosed are an indane compound represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted mono-cyclic aromatic heterocyclic group having nitrogen atom as a hetero atom; R.sup.2 represents hydrogen atom or a lower alkyl group; and A represents a lower alkylene group, or a pharmaceutically acceptable salt thereof and processes for preparing the same.

摘要翻译： 公开了下式表示的二氢化茚化合物：其中R 1表示低级烷基，低级链烯基或具有氮原子作为杂原子的取代或未取代的单环芳族杂环基; R2表示氢原子或低级烷基; A表示低级亚烷基或其药学上可接受的盐及其制备方法。

公开(公告)号：US5698554A

公开(公告)日：1997-12-16

申请号：US671485

申请日：1996-06-27

申请人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Harutami Yamada ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： A61K31/50 ,  A61K31/501 ,  A61P13/12 ,  C07D237/14 ,  C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D413/12

CPC分类号： C07D401/12 ,  C07D237/14 ,  C07D403/12 ,  C07D409/12

摘要： Disclosed is a pyridazinone compound represented by the formula (I): ##STR1## wherein X represents hydrogen atom or the like; Y represents a single bonding arm, oxygen atom or sulfur atom; A represents a straight or branched alkylene group which may have a double bond; B represents carbonyl group or thiocarbonyl group; and R.sup.2 represents an alkyl group having 1 to 10 carbon atoms which may be substituted or the like; or B represents sulfonyl group; and R.sup.2 represents a lower alkenyl group or the like; R.sup.1 represents hydrogen atom or the like; R.sup.3 represents hydrogen atom or the like; R.sup.4 represents hydrogen atom or the like; and R.sup.5 represents hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.

摘要翻译： 公开了由式（I）表示的哒嗪酮化合物：其中X表示氢原子等;（I） Y表示单键键，氧原子或硫原子; A表示可以具有双键的直链或支链亚烷基; B表示羰基或硫代羰基; R 2表示可以具有取代基的碳原子数1〜10的烷基等。 或B表示磺酰基; 并且R 2表示低级烯基等; R1表示氢原子等; R3表示氢原子等; R4代表氢原子等; R5代表氢原子等，或其药学上可接受的盐。

公开(公告)号：US5605901A

公开(公告)日：1997-02-25

申请号：US365289

申请日：1994-12-28

申请人： Akihiko Ishida ,  Koichi Homma ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

发明人： Akihiko Ishida ,  Koichi Homma ,  Michihisa Yato ,  Shinsuke Nishiyama ,  Fumikazu Okumura

IPC分类号： C07D237/04 ,  C07D237/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D401/10 ,  A61K31/50

CPC分类号： C07D401/12 ,  C07D237/04 ,  C07D237/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed are an indane compound represented by the formula: ##STR1## wherein R.sup.1 is aryl, lower alkyl, cycloalkyl, halogeno-lower alkyl, lower alkenyl, phenyl-substituted lower alkenyl, monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, lower alkoxy, phenoxy, lower alkylamino, lower alkenylamino, phenyl-amino, lower alkyl substituted by monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, or lower alkenyloxy; R.sup.2 is H or lower alkyl; X is carbonyl or thiocarbonyl; Alk is single bonding arm or lower alkylene; and the dotted line is presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a synthetic intermediate thereof.

摘要翻译： 公开了由下式表示的二氢化茚化合物：其中R 1为芳基，低级烷基，环烷基，卤代低级烷基，低级烯基，苯基取代的低级烯基，单环或双环芳族杂环，其具有N，O或 S为杂原子，低级烷氧基，苯氧基，低级烷基氨基，低级链烯基氨基，苯基 - 氨基，被N，O或S为杂原子的单环或双环芳族杂环取代的低级烷基或低级烯氧基; R2是H或低级烷基; X是羰基或硫代羰基; Alk是单键或低级亚烷基; 虚线是双键存在或不存在，或其药学上可接受的盐，其制备方法及其合成中间体。