公开(公告)号：US5401517A

公开(公告)日：1995-03-28

申请号：US153015

申请日：1993-11-15

申请人： Alan J. Meyers ,  Alan Evenson ,  Peter Dorogi ,  John P. McCook

发明人： Alan J. Meyers ,  Alan Evenson ,  Peter Dorogi ,  John P. McCook

IPC分类号： A61K8/00 ,  A61K8/67 ,  A61K31/07 ,  A61P17/00 ,  A61Q19/00 ,  A61K7/48

CPC分类号： A61Q19/00 ,  A61K8/671 ,  A61K2800/75 ,  A61K2800/884 ,  Y10S514/828 ,  Y10S514/844 ,  Y10S514/846 ,  Y10S514/847

摘要： A method is provided for improving skin condition through a system whose steps include applying to the skin separately on a plurality of days a first composition that incorporates a retinoid which is either retinol or retinoic acid in a pharmaceutically acceptable carrier. Once the skin has acclimated to any irritation induced by the first composition, a second composition is applied to the skin daily for a subsequent period of time. The second composition will also include retinoid but at a level at least about 10% higher than that employed in the first composition. Once the skin has acclimated to the second composition, subsequent progressive increases of the active retinoid can be applied over subsequent periods of time. Finally, a maintenance level composition is utilized with the highest level of retinoid in the progressive program to minimize potential irritation.

摘要翻译： 提供了一种通过系统改善皮肤状况的方法，该系统的步骤包括在多天内分别施用第一种组合物，该第一组合物在药学上可接受的载体中掺入视黄醇或视黄酸。 一旦皮肤适应于由第一组合物引起的任何刺激，将第二组合物每天施用于皮肤随后的一段时间。 第二组合物还将包括类视黄醇，但其含量比第一组合物中使用的水平高至少约10％。 一旦皮肤适应第二种组合物，随后的活性类视色素的随后逐渐增加可以在随后的时间段内施用。 最后，维持级别组合物被用于渐进方案中最高水平的类视黄醇，以尽量减少潜在的刺激。