公开(公告)号：US20230117777A1

公开(公告)日：2023-04-20

申请号：US17910042

申请日：2021-03-30

Applicant: Amgen Inc.

Inventor： Michal ACHMATOWICZ ,  Sheng CUI ,  Tsang-Lin HWANG ,  Neil Fred LANGILLE ,  Janine K. TOM ,  James E. HUCKLE ,  Markian STEC ,  Tian WU ,  Sean P. BROWN

IPC: C07D519/00

Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).