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公开(公告)号：US20230167130A1
公开(公告)日：2023-06-01
申请号：US17922619
申请日：2021-05-05
Applicant: AMGEN INC.
Inventor： Austin G. SMITH , Jason S. TEDROW , Gabrielle ST-PIERRE , Oliver Ralf THIEL , Liang HUANG , Philipp C. ROOSEN , John T. COLYER , Kyle D. BAUCOM , Ari ERICSON , Matthew G. BEAVER , Rahul P. SANGODKAR , Michael A. LOVETTE , Robert Ronald MILBURN , Alan H. CHERNEY , Sheng CUI
IPC: C07D513/10 , C07D267/16
CPC classification number: C07D513/10 , C07D267/16
Abstract: Provided herein are processes for synthesizing Mcl-1 inhibitors and intermediates such as compound F that can be used to prepare them where the variable PG is as defined herein. In particular, provided herein are processes for synthesizing compound A1, and salts or solvates thereof and compound A2, and salts and solvates thereof.
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公开(公告)号：US20130345432A1
公开(公告)日：2013-12-26
申请号：US13955343
申请日：2013-07-31
Applicant: Amgen Inc.
Inventor： Seb CAILLE , Sheng CUI , Xiang WANG , Margaret FAUL
IPC: C07D277/54
CPC classification number: C07D277/54
Abstract: The invention provides two process for synthesizing substituted aminothiazolone compounds as inhibitors of 11-β-hydroxy steroid dehydrogenase type 1. The processes allow the stereoselective synthesis of the desired compounds without the use of stoichiometric amounts of chiral catalysts.
Abstract translation: 本发明提供两种合成取代的氨基噻唑酮化合物作为11型11-β-羟基类固醇脱氢酶抑制剂的方法。该方法允许所需化合物的立体选择性合成而不使用化学计量的手性催化剂。
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公开(公告)号：US20170190739A1
公开(公告)日：2017-07-06
申请号：US15300209
申请日：2015-04-03
Applicant: AMGEN INC.
Inventor： Jeroen BEZEMER , Ying CHEN , Richard CROCKETT , Kevin CROSSLEY , Sheng CUI , Liang HUANG , Sian JONES , Asher LOWER , Krishnakumar RANGANATHAN
CPC classification number: C07K7/06 , A61K38/00 , C07K1/1075
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease—mineral and bone disorder (CKD-MBD).
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公开(公告)号：US20210284617A1
公开(公告)日：2021-09-16
申请号：US16327079
申请日：2017-08-03
Applicant: Amgen Inc.
Inventor： Matthew BEAVER , Sheng CUI , Xiangqing SHI
IPC: C07D301/12 , B01J31/16
Abstract: The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.
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Patent Agency Ranking
公开(公告)号：US20240199550A1
公开(公告)日：2024-06-20
申请号：US18416741
申请日：2024-01-18
Applicant: Amgen Inc. , Cytokinetics, Inc.
Inventor： Henry MORRISON , Sheng CUI , Kyle QUASDORF , Evelyn YANEZ , Bin Peter QUAN , Ron C. KELLY , Sebastien CAILLE , Lingyun XIAO , David PEARSON , Jaclyn RAEBURN , Alisa GOLIGHTLY , Bradley MORGAN , Matthew PETERSON , Alex EBERLIN , Alexander OBLEZOV
IPC: C07D213/75
CPC classification number: C07D213/75 , C07B2200/13
Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US20230183164A1
公开(公告)日：2023-06-15
申请号：US17920084
申请日：2021-05-04
Applicant: AMGEN INC.
Inventor： Austin G. SMITH , Michael T. CORBETT , Neil Fred LANGILLE , Kyle D. BAUCOM , Peter K. DORNAN , Gabrielle ST- PIERRE , Philipp C. ROOSEN , Sheng CUI , Roberto PROFETA
IPC: C07C67/62 , C07D249/18 , C07D519/00 , C07D513/08
CPC classification number: C07C67/62 , C07D249/18 , C07D519/00 , C07D513/08 , C07B2200/13
Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.
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公开(公告)号：US20230117777A1
公开(公告)日：2023-04-20
申请号：US17910042
申请日：2021-03-30
Applicant: Amgen Inc.
Inventor： Michal ACHMATOWICZ , Sheng CUI , Tsang-Lin HWANG , Neil Fred LANGILLE , Janine K. TOM , James E. HUCKLE , Markian STEC , Tian WU , Sean P. BROWN
IPC: C07D519/00
Abstract: Disclosed herein is an improved process for the synthesis of compound (A): (A), or a salt or solvate thereof via methylation of compound (B): (B), or a salt or solvate thereof, a crystalline hydrate of compound A, and pharmaceutical formulations comprising a crystalline hydrate of compound (A).
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公开(公告)号：US20230099078A1
公开(公告)日：2023-03-30
申请号：US17852263
申请日：2022-06-28
Applicant: AMGEN INC.
Inventor： Jeroen BEZEMER , Ying CHEN , Richard CROCKETT , Kevin CROSSLEY , Sheng CUI , Liang HUANG , Sian JONES , Asher LOWER , Krishnakumar RANGANATHAN
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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公开(公告)号：US20190352336A1
公开(公告)日：2019-11-21
申请号：US16532344
申请日：2019-08-05
Applicant: AMGEN INC.
Inventor： Jeroen BEZEMER , Ying CHEN , Richard CROCKETT , Kevin CROSSLEY , Sheng CUI , Liang HUANG , Sian JONES , Asher LOWER , Krishnakumar RANGANATHAN
Abstract: A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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