公开(公告)号：US20240182477A1

公开(公告)日：2024-06-06

申请号：US18472147

申请日：2023-09-21

Applicant: AMGEN INC. ,  VIGIL NEUROSCIENCE, INC.

Inventor： Lara C. CZABANIUK ,  Timothy HOPPER ,  Jonathan B. HOUZE ,  Jane PANTELEEV ,  Gwenaella RESCOURIO ,  Vincent SANTORA ,  Haoxuan WANG ,  Ryan D. WHITE ,  Alice R. WONG ,  Yongwei WU ,  Maxence BOS ,  John MANCUSO ,  Ivan FRANZONI

IPC: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04 ,  C07D475/00

CPC classification number: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04 ,  C07D475/00

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).




This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US20230295169A1

公开(公告)日：2023-09-21

申请号：US18072501

申请日：2022-11-30

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. CZABANIUK ,  Timothy HOPPER ,  Jonathan B. HOUZE ,  Jane PANTELEEV ,  Gwenaella RESCOURIO ,  Vincent SANTORA ,  Haoxuan WANG ,  Ryan D. WHITE ,  Alice R. WONG ,  Yongwei WU ,  Maxence BOS ,  John MANCUSO ,  Ivan FRANZONI

IPC: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D487/04 ,  A61P25/28 ,  C07D413/14 ,  C07D471/04

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”).




This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US20230002390A1

公开(公告)日：2023-01-05

申请号：US17302502

申请日：2021-05-04

Applicant: AMGEN INC. ,  Vigil Neuroscience, Inc.

Inventor： Lara C. CZABANIUK ,  Timothy HOPPER ,  Jonathan B. HOUZE ,  Jane PANTELEEV ,  Gwenaella RESCOURIO ,  Vincent SANTORA ,  Haoxuan WANG ,  Ryan D. WHITE ,  Alice R. WONG ,  Yongwei WU ,  Maxence BOS ,  John MANCUSO ,  Ivan FRANZONI

IPC: C07D487/04 ,  A61P25/28 ,  C07D471/04 ,  C07D413/14

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

公开(公告)号：US20200308145A1

公开(公告)日：2020-10-01

申请号：US16754349

申请日：2018-10-18

Applicant: Amgen Inc.

Inventor： Michael D. BARTBERGER ,  Nagasree CHAKKA ,  Hua GAO ,  Angel GUZMAN-PEREZ ,  Daniel B. HORNE ,  Zihao HUA ,  Madeleine KIEFFER ,  Daniel C. H. Lin ,  Benjamin Charles MILGRAM ,  Jane PANTELEEV ,  Laurie SCHENKEL ,  John STELLWAGEN ,  Matthew WEISS ,  Ryan D. WHITE ,  Wei ZHAO

IPC: C07D401/14 ,  C07D471/10 ,  C07D471/04 ,  C07D498/04 ,  C07D401/04 ,  C07D403/04 ,  C07D413/14

Abstract: The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.