公开(公告)号：US20240245686A1

公开(公告)日：2024-07-25

申请号：US18545932

申请日：2023-12-19

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61K31/555 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K31/555 ,  C07K16/2818

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as




or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20230121955A1

公开(公告)日：2023-04-20

申请号：US17870573

申请日：2022-07-21

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61P35/00 ,  C07K16/28 ,  A61K31/555

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20240173328A1

公开(公告)日：2024-05-30

申请号：US18545953

申请日：2023-12-19

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61K31/555

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as




or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

公开(公告)号：US20200222407A1

公开(公告)日：2020-07-16

申请号：US16687563

申请日：2019-11-18

Applicant: Amgen Inc.

Inventor： James Russell LIPFORD ,  Jude Robert CANON ,  Anne Y. SAIKI ,  Karen Louise REX

IPC: A61K31/519 ,  A61P35/00

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.