专利检索 ap:("Amgen Inc.") AND inv:"Xiangqing SHI" 第 1 页

1.

发明申请
Synthesis of (S)-2-Amino-4-Methyl-((R)-2-Methyloxirane-2-Yl)-Pentan-1-One and Pharmaceutically Acceptable Salts Thereof 有权

公开(公告)号：US20210284617A1

公开(公告)日：2021-09-16

申请号：US16327079

申请日：2017-08-03

申请人： Amgen Inc.

发明人： Matthew BEAVER , Sheng CUI , Xiangqing SHI

IPC分类号： C07D301/12 , B01J31/16

摘要： The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.