公开(公告)号：US20030099990A1

公开(公告)日：2003-05-29

申请号：US10251947

申请日：2002-09-20

申请人： Amgen Inc. A Corporation of the State of Delaware

发明人： Hailing Hsu

IPC分类号： C12Q001/68 ,  G01N033/53 ,  G01N033/567 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06 ,  C07K014/705

CPC分类号： C07K14/70578 ,  A61K38/00

摘要： The present invention provides tumor necrosis factor and apoptosis ligand-related leukocyte-expressed ligand 1 receptor (TALL-1R) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TALL-1R polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TALL-1R polypeptides.

摘要翻译： 本发明提供肿瘤坏死因子和凋亡配体相关白细胞表达的配体1受体（TALL-1R）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生TALL-1R多肽的方法。 本发明进一步提供用于诊断，治疗，改善和/或预防与TALL-1R多肽相关的疾病，病症和病症的药物组合物和方法。