公开(公告)号：US20230089497A1

公开(公告)日：2023-03-23

申请号：US17909345

申请日：2021-03-03

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Qi ZHANG ,  Xiao WANG ,  Alexander GREEN ,  Duo MA ,  Fuqing WU ,  Kylie STANDAGE-BEIER ,  Xingwen CHEN

IPC: C12N15/67

Abstract: The present invention provides a new class of RNA modules, referred to as degradation tuning RNAs (dtRNAs), which form stabilizing secondary structures. Also provided are methods of using dtRNAs to modulate the stability of RNAs. DNA constructs including a promoter that is operably connected to a sequence encoding the dtRNA are also provided.

公开(公告)号：US20190256898A1

公开(公告)日：2019-08-22

申请号：US16342722

申请日：2017-10-17

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Alexander GREEN ,  Duo MA ,  Anli TANG

IPC: C12Q1/6825

Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.