公开(公告)号：US20230089497A1

公开(公告)日：2023-03-23

申请号：US17909345

申请日：2021-03-03

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Qi ZHANG ,  Xiao WANG ,  Alexander GREEN ,  Duo MA ,  Fuqing WU ,  Kylie STANDAGE-BEIER ,  Xingwen CHEN

IPC: C12N15/67

Abstract: The present invention provides a new class of RNA modules, referred to as degradation tuning RNAs (dtRNAs), which form stabilizing secondary structures. Also provided are methods of using dtRNAs to modulate the stability of RNAs. DNA constructs including a promoter that is operably connected to a sequence encoding the dtRNA are also provided.