公开(公告)号：US10401298B2

公开(公告)日：2019-09-03

申请号：US15878277

申请日：2018-01-23

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Nongjian Tao ,  Yan Guan

IPC: G01N33/50 ,  G01N21/77 ,  G02B21/36

Abstract: A system for quantitative detection and analysis of the interactions of molecules with molecular receptors on the surfaces of biological cells based on detecting a mechanical deformation in the membrane of a cell associated with the molecular interactions, which works for both large and small molecules. The mechanical deformation can be detected with high precision in real time from an optical image of the cell with a differential detection method. The system can be also used to detect the electrical activities, such as ion channel opening and closing, as well as action potential propagation in neuronal cells.