公开(公告)号：US09790206B2

公开(公告)日：2017-10-17

申请号：US14770035

申请日：2014-02-27

Applicant: Array BioPharma Inc.

Inventor： C. Todd Eary ,  Bruno P. Hache ,  Derrick Juengst ,  Stacey Renee Spencer ,  Peter J. Stengel ,  Daniel John Watson

IPC: C07D403/12 ,  C07D231/56

CPC classification number: C07D403/12 ,  C07D231/56

Abstract: Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

公开(公告)号：US20170087156A1

公开(公告)日：2017-03-30

申请号：US15311148

申请日：2015-05-14

Applicant: Array BioPharma Inc.

Inventor： Shelley Allen ,  Steven W. Andrews ,  Brian Baer ,  Zackary Crane ,  Weidong Liu ,  Daniel John Watson

IPC: A61K31/506 ,  A61K9/00 ,  C07D207/16 ,  C07D403/14 ,  A61K45/06

CPC classification number: A61K31/506 ,  A61K9/0053 ,  A61K45/06 ,  C07D207/16 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14

Abstract: Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.

公开(公告)号：US20160002210A1

公开(公告)日：2016-01-07

申请号：US14770035

申请日：2014-02-27

Applicant: ARRAY BIOPHARMA INC.

Inventor： Todd C. Eary ,  Bruno P. Hache ,  Derrick Juengst ,  Stacey Renee Spencer ,  Peter J. Stengel ,  Daniel John Watson

IPC: C07D403/12 ,  C07D231/56

CPC classification number: C07D403/12 ,  C07D231/56

Abstract: Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.

Abstract translation: 本文提供了制备式（I）化合物以在合成吲唑衍生物的新方法中使用所述化合物作为中间体的新方法，以及通过本文所述的方法制备的吲唑中间体和衍生物。