公开(公告)号：US20240365659A1

公开(公告)日：2024-10-31

申请号：US18575050

申请日：2022-07-01

申请人： Samsung Display Co., Ltd.

发明人： Michael DANZ ,  Nico-Patrick THÖBES

IPC分类号： H10K85/60 ,  C07D403/14 ,  C07D491/048 ,  C09K11/06 ,  H10K50/11 ,  H10K71/12 ,  H10K71/16

CPC分类号： H10K85/654 ,  C07D403/14 ,  C07D491/048 ,  C09K11/06 ,  H10K85/657 ,  H10K85/6572 ,  C09K2211/1018 ,  H10K50/11 ,  H10K71/12 ,  H10K71/164

摘要： The invention relates to an organic molecule for the application in optoelectronic devices. According to the invention, the organic molecule has



a first chemical moiety including of a structure of Formula I:








and



one or two second chemical moieties, including a structure of Formula II:










wherein
the first chemical moiety is linked to the second chemical moiety via a single bond;
W is the binding site of a single bond linking the first chemical moiety to the second chemical moiety,
Q is W or is R1,
# represents the binding site of the first chemical moiety to the second chemical moiety;
Z is at each occurrence independently from each other selected from the group consisting of a direct bond, CR3R4, C═CR3R4, C═O, C═NR3, NR3, O, SiR3R4, S, S(O), and S(O)2.

公开(公告)号：US20240360121A1

公开(公告)日：2024-10-31

申请号：US18597265

申请日：2024-03-06

申请人： Board of Regents, The University of Texas System

发明人： Maria Emilia DI FRANCESCO ,  Philip JONES ,  Timothy HEFFERNAN ,  Matthew M. HAMILTON ,  Zhijun KANG ,  Michael J. SOTH ,  Jason P. BURKE ,  Kang LE ,  Christopher Lawrence CARROLL ,  Wylie S. PALMER ,  Richard LEWIS ,  Timothy MCAFOOS ,  Barbara CZAKO ,  Gang LIU ,  Jay THEROFF ,  Zachary HERRERA ,  Anne YAU

IPC分类号： C07D417/14 ,  A61K31/4192 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D417/06 ,  C07D493/08

CPC分类号： C07D417/14 ,  A61K31/4192 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/454 ,  A61K31/497 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D417/06 ,  C07D493/08

摘要： Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I:




Methods of inhibition GLS1 activity in a human or animal subject are also provided.

公开(公告)号：US20240360106A1

公开(公告)日：2024-10-31

申请号：US18605379

申请日：2024-03-14

申请人： XIZANG HAISCO PHARMACEUTICAL CO., LTD.

发明人： Bohan JIN ,  Qing DONG ,  Gene HUNG

IPC分类号： C07D403/14 ,  A61P5/14 ,  C07D413/14

CPC分类号： C07D403/14 ,  A61P5/14 ,  C07D413/14

摘要： Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.

公开(公告)号：US20240360103A1

公开(公告)日：2024-10-31

申请号：US18573634

申请日：2022-06-30

申请人： Apellis Pharmaceuticals, Inc.

发明人： Johannes Wilhelm Georg Meissner ,  Andrew Simon Cook ,  Mark William Orme

IPC分类号： C07D401/14 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D401/14 ,  A61K31/496 ,  A61K31/501 ,  A61K31/506 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： Among other things, the present disclosure provides technologies for modulating complement activation. In some embodiments, the present disclosure provides compounds that inhibit C3 convertase activity. In some embodiments, the present disclosure provides methods for treating complement-mediated conditions, disorders or diseases. In some embodiments, the present disclosure provides methods for treating conditions, disorders or diseases mediated by C3 convertase.

公开(公告)号：US12129250B2

公开(公告)日：2024-10-29

申请号：US18372417

申请日：2023-09-25

申请人： LYNK PHARMACEUTICALS CO. LTD.

发明人： Zhaokui Wan ,  Michael Lawrence Vazquez ,  Gurmit Grewal ,  Xiaodong Li ,  Lin Su ,  Jingyu Wu

IPC分类号： C07D471/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/18 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D495/04 ,  C07D498/08 ,  C07D498/18

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/18 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D495/04 ,  C07D498/08 ,  C07D498/18

摘要： The invention provides a novel class of therapeutic agents that are safe and effective TYK2 inhibitors and pharmaceutical compositions of these compounds and methods of preparation and use thereof against various TYK2-mediated diseases and disorders.

公开(公告)号：US20240351984A1

公开(公告)日：2024-10-24

申请号：US18735162

申请日：2024-06-05

申请人： Volastra Therapeutics, Inc.

发明人： Derek A. COGAN

IPC分类号： C07D209/96 ,  A61P35/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D491/107 ,  C07D491/113 ,  C07F9/572

CPC分类号： C07D209/96 ,  A61P35/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D491/107 ,  C07D491/113 ,  C07F9/5728

摘要： The present disclosure relates generally to inhibitors of KIF18A, compositions thereof, and methods of using said compounds and compositions thereof. More specifically, the present disclosure relates to indoline inhibitors of KIF18A and methods of their use for treating disease mediated by KIF18A, such as cancer.

公开(公告)号：US20240336599A1

公开(公告)日：2024-10-10

申请号：US18611785

申请日：2024-03-21

申请人： PROMERUS, LLC

发明人： PRAMOD KANDANARACHCHI ,  LARRY F. RHODES

IPC分类号： C07D403/14 ,  C08G73/10 ,  C08K5/3442 ,  G03F7/004 ,  G03F7/038

CPC分类号： C07D403/14 ,  C08G73/105 ,  C08K5/3442 ,  G03F7/0045 ,  G03F7/0387

摘要： Embodiments in accordance with the present invention encompass a composition comprising a polyamic acid or an end capped polyamic acid and a diazirine, which are useful as photosensitive compositions for forming films that can be patterned to create structures for microelectronic devices, microelectronic packaging, microelectromechanical systems, optoelectronic devices and displays. In some embodiments the compositions of this invention are shown to feature excellent hitherto unachievable mechanical properties. The negative images formed therefrom exhibit improved thermo-mechanical properties, among other property enhancements.

公开(公告)号：US20240336574A1

公开(公告)日：2024-10-10

申请号：US18280891

申请日：2022-03-10

申请人： LATIGO BIOTHERAPEUTICS, INC. ,  LIEBER INSTITUTE, INC.

发明人： Robert M. Jones ,  Ashok Bajji ,  Nathaniel Julius Thomas Monck ,  Suzanne J. O'Connor ,  William H. Gardiner ,  Robert James Townsend ,  Andreina Pacheco Pita ,  Michael Brunavs ,  Abdul Kadar Shaikh ,  Jonathan Paul Shine ,  Ian James Wigginton ,  Jonathan Philip Richards ,  Marco Michele Mastandrea ,  Adam James Davenport ,  Bryan Moyer ,  Michael Poslusney ,  James Barrow ,  Richard Edmund Rathmell

IPC分类号： C07D237/24 ,  A61K31/455 ,  A61K31/4725 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/82 ,  C07D237/26 ,  C07D239/26 ,  C07D241/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04

CPC分类号： C07D237/24 ,  A61K31/455 ,  A61K31/4725 ,  A61K31/50 ,  A61K31/501 ,  A61K31/502 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/82 ,  C07D237/26 ,  C07D239/26 ,  C07D241/24 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04

摘要： The invention provides methyl-substituted pyridine and pyridazine compounds, derivatives thereof, and methods of their use. The compounds are useful as pharmacological agents to treat a variety of conditions, including various pain states, itch, and cough.

公开(公告)号：US20240334822A1

公开(公告)日：2024-10-03

申请号：US18732952

申请日：2024-06-04

申请人： SAMSUNG SDI CO., LTD.

发明人： Yongtak YANG ,  Dong Min KANG ,  Hyung Sun KIM ,  Jinhyun LUI ,  Seungin PARK ,  Jaejin OH ,  Sung-Hyun JUNG ,  Ho Kuk JUNG ,  Youngkyoung JO ,  Pyeongseok CHO ,  Dalho HUH

IPC分类号： H10K85/60 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07F15/00 ,  C09K11/06 ,  H10K50/11 ,  H10K85/30 ,  H10K101/10

CPC分类号： H10K85/654 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D487/04 ,  C07F15/0033 ,  C07F15/0086 ,  C09K11/06 ,  H10K85/342 ,  H10K85/346 ,  H10K85/6572 ,  H10K85/6574 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/185 ,  H10K50/11 ,  H10K2101/10

摘要： A composition for an organic optoelectronic device, an organic optoelectronic device, and a display device, the composition including a first compound; a second compound; and a third compound, the first compound, the second compound, and the third compound are different from each other, the first compound is represented by Chemical Formula I, the second compound is represented by Chemical Formula II or Chemical Formula III, and the third compound is represented by Chemical Formula II or Chemical Formula III,

公开(公告)号：US20240327402A1

公开(公告)日：2024-10-03

申请号：US18576252

申请日：2022-08-03

申请人： ABBISKO THERAPEUTICS CO., LTD.

发明人： Tao FENG ,  Baowei ZHAO ,  Mingming ZHANG ,  Shuqun YANG ,  Hongping YU ,  Zhui CHEN ,  Yaochang XU

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61P35/00 ,  C07D403/04 ,  C07D403/14 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/506 ,  A61P35/00 ,  C07D403/04 ,  C07D403/14 ,  C07D519/00

摘要： A pyrimidine or pyridine derivative having a structure represented by formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use thereof as an EGFR inhibitor, and a use thereof in the preparation of a drug for treating and/or preventing cancer, tumors, or metastatic diseases associated at least in part with EGFR exon 20 insertions, deletions, or other mutations, especially a use thereof in the preparation of a drug for treating and/or preventing hyperproliferative diseases and the induction of cell death disorders.