公开(公告)号：US20220288074A1

公开(公告)日：2022-09-15

申请号：US17338767

申请日：2021-06-04

Applicant: Array BioPharma Inc.

Inventor： Patrick Michael DOERNER BARBOUR ,  Tanna Marie BETTENDORF ,  Dean Russell KAHN ,  Alex Andrew KELLUM ,  Ellen Ruth LAIRD ,  David Austin MORENO ,  Li REN

IPC: A61K31/517 ,  A61K45/06 ,  A61K31/4184 ,  A61K39/395 ,  C07D403/12 ,  C07D239/90 ,  C07D487/08 ,  C07D405/12 ,  C07D401/12 ,  C07D471/08 ,  A61K31/5377

Abstract: Provided herein is a compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors.

公开(公告)号：US20220289721A1

公开(公告)日：2022-09-15

申请号：US17745346

申请日：2022-05-16

Applicant: Array BioPharma Inc.

Inventor： Patrick Michael BARBOUR ,  Katie Keaton BROWN ,  Adam Wade COOK ,  Erik James HICKEN ,  Dean Russell KAHN ,  Ellen Ruth LAIRD ,  Andrew Terrance METCALF ,  David Austin MORENO ,  Bradley Jon NEWHOUSE ,  Spencer Phillip PAJK ,  Brett Joseph PRIGARO ,  Li REN ,  Eugene TARLTON

IPC: C07D403/12 ,  C07D239/90 ,  C07D239/91

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.