公开(公告)号：US20220288074A1

公开(公告)日：2022-09-15

申请号：US17338767

申请日：2021-06-04

Applicant: Array BioPharma Inc.

Inventor： Patrick Michael DOERNER BARBOUR ,  Tanna Marie BETTENDORF ,  Dean Russell KAHN ,  Alex Andrew KELLUM ,  Ellen Ruth LAIRD ,  David Austin MORENO ,  Li REN

IPC: A61K31/517 ,  A61K45/06 ,  A61K31/4184 ,  A61K39/395 ,  C07D403/12 ,  C07D239/90 ,  C07D487/08 ,  C07D405/12 ,  C07D401/12 ,  C07D471/08 ,  A61K31/5377

Abstract: Provided herein is a compound of the Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7 and L are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors.