公开(公告)号：US20250090464A1

公开(公告)日：2025-03-20

申请号：US18727804

申请日：2023-02-03

Applicant: BASF SE

Inventor： Lukas Ries ,  Thorsten Cech ,  Elesabeth Gruenstein ,  Felicitas Guth ,  Karl Kolter

IPC: A61K9/16

Abstract: The present invention relates to a powder mixture for the preparation of a granulate comprising as constituent at least a filler or at least an active ingredient or both and as granulation aid Magnesium diacetate×4H2O and/or Magnesium dichloride×6H2O and/or Magnesium sulfate×7H2O and/or Disodium sulfate xH2O and/or Sodium thiosulfate×5H2O and/or Na3PO4×12H2O and/or Na2HPO4×12H2O/7H2O and/or Sodium acetate×3H2O. Optionally constituents of the powder mixture to be granulated are binders, disintegrants and further customary auxiliaries. It was an object of the present invention to provide a powder mixture which can be granulated without adding a liquid but where the water for the granulation is released in-situ from Magnesium diacetate×4H2O and/or Magnesium dichloride×6H2O and/or Magnesium sulfate×7H2O and/or Disodium sulfate xH2O and/or Sodium thiosulfate×5H2O and/or Na3PO4×12H2O and/or Na2HPO4×12H2O/7H2O and/or Sodium acetate×3H2O. An additional drying step is not required.