公开(公告)号：US11993759B2

公开(公告)日：2024-05-28

申请号：US15768642

申请日：2016-10-13

Applicant: BASF SE

Inventor： Karl Kolter ,  Ralf Pelzer ,  Matthias Karl

IPC: A61K8/02 ,  A23L27/00 ,  A23L27/20 ,  A61K8/34 ,  A61K8/81 ,  A61K9/20 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/46 ,  A61L9/01 ,  A61Q13/00 ,  C11B9/00 ,  C11D3/00 ,  C11D3/37 ,  C11D3/50

CPC classification number: C11B9/0015 ,  A23L27/2026 ,  A23L27/203 ,  A23L27/74 ,  A61K8/0287 ,  A61K8/34 ,  A61K8/817 ,  A61K8/8182 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61K47/46 ,  A61L9/01 ,  A61Q13/00 ,  C11B9/0034 ,  C11D3/00 ,  C11D3/3776 ,  C11D3/3788 ,  C11D3/505 ,  A23V2002/00

Abstract: An optically clear, solid water-soluble formulation of odorants and flavorings comprising at least one synthetically prepared odorant and flavoring, in which the odorants and flavorings are embedded homogeneously in a polymer matrix based on polyvinyllactams.

公开(公告)号：US10328150B2

公开(公告)日：2019-06-25

申请号：US15362957

申请日：2016-11-29

Applicant: BASF SE

Inventor： Karl Kolter ,  Dejan Djuric ,  Stefan Fischer

IPC: C08F283/06 ,  A61K9/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K31/55 ,  A61K31/192 ,  A61K31/216 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/635 ,  A61K31/4164 ,  A61K31/4425 ,  A61K31/5415

Abstract: Dosage forms comprising preparations of slightly water-soluble active substances in a polymer matrix of polyether copolymers, the polyether copolymers being obtained by free radical polymerization of a mixture of from 30 to 80% by weight of N-vinyllactam, from 10 to 50% by weight of vinyl acetate and from 10 to 50% by weight of a polyether, and of at least one slightly water-soluble polymer in which the slightly water-soluble active substance is present in amorphous form in the polymer matrix.

公开(公告)号：US09744240B2

公开(公告)日：2017-08-29

申请号：US14036445

申请日：2013-09-25

Applicant: BASF SE

Inventor： Felicitas Guth ,  Karl Kolter ,  Michael Schönherr ,  Franz Weber

IPC: A61K47/00 ,  A61K47/22 ,  A61K47/32

CPC classification number: A61K47/22 ,  A61K47/32

Abstract: A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble Vitamin E-derivative and at least one hydrophilic polymer. In one embodiment the storage-stable dust-free homogeneous particle formulation, consists of (a) at least one water-soluble Vitamin E-derivative, (b) at least one hydrophilic polymer, (c) optionally additional surface-active substances, and (d) optionally additional pharmaceutical additives, with the proviso, that the sum of (a), (b), (c) and (d) equals 100% by weight of the formulation, and wherein the fines fraction with particle diameters of less than 100 μm is less than 10% by weight. Methods of making the particulate formulation by a spray granulation process are also provided.

公开(公告)号：US20150038668A1

公开(公告)日：2015-02-05

申请号：US14499528

申请日：2014-09-29

Applicant: BASF SE

Inventor： Dejan Djuric ,  Monika Haberecht ,  Karl Kolter ,  Bernd Bruchmann

IPC: C08G63/133

CPC classification number: C08G63/133 ,  A61K9/146 ,  A61K9/1641 ,  A61K9/1676 ,  A61K9/2031 ,  A61K9/7007 ,  C08G63/12 ,  C08G63/85

Abstract: Branched polyesters obtained by polycondensation of citric acid with at least one poly-alcohol having at least two hydroxyl groups and, if desired, further polycarboxylic acid components, the molar ratio of citric acid to polyalcohol being 2.4:1 to 1:3.

Abstract translation: 通过柠檬酸与至少一种具有至少两个羟基的多元醇缩聚获得的支化聚酯，以及如果需要，进一步的多元羧酸组分，柠檬酸与多元醇的摩尔比为2.4:1至1:3。

公开(公告)号：US20130345320A1

公开(公告)日：2013-12-26

申请号：US13919092

申请日：2013-06-17

Applicant: BASF SE

Inventor： Karl Kolter ,  Maximilian Angel ,  Matthias Karl ,  Silke Gebert ,  Michael Klemens Müller

IPC: A61K47/32

CPC classification number: A61K47/32 ,  A61K9/146 ,  A61K9/1635

Abstract: Described are solid dispersions of hydrophobic active ingredients and cationic copolymers of N,N-diethylaminoethyl methacrylate and methyl methacrylate in a weight ratio of the monomers of from 35:65 to 55:45. Also described are the preparation and use of such solid dispersions for pharmaceutical dosage forms.

Abstract translation: 描述了单体重量比为35:65至55:45的疏水性活性成分和甲基丙烯酸N，N-二乙基氨基乙酯和甲基丙烯酸甲酯的阳离子共聚物的固体分散体。 还描述了用于药物剂型的这种固体分散体的制备和用途。

公开(公告)号：US20130236505A1

公开(公告)日：2013-09-12

申请号：US13790101

申请日：2013-03-08

Applicant: BASF SE

Inventor： Karl Kolter ,  Silke Gebert ,  Michael Klemens Müller ,  Maximilian Angel

IPC: A61K47/32 ,  A61K47/12 ,  A61K9/00

CPC classification number: A61K47/32 ,  A61K9/0002 ,  A61K9/282 ,  A61K9/2846 ,  A61K9/5015 ,  A61K9/5026 ,  A61K47/12

Abstract: Pharmaceutical coatings obtained from coating compositions based on film-forming copolymers of N,N-diethylaminoethyl methacrylate (DEAEMA) and methyl methacrylate (MMA) comprising a weight ratio of DEAEMA:MMA in the range of 35:65 to 55:45, where the copolymers are present partially neutralized with C3-C10-dicarboxylic acids.

Abstract translation: 由基于N，N-二乙基氨基乙基甲基丙烯酸酯（DEAEMA）和甲基丙烯酸甲酯（MMA）的成膜共聚物的涂料组合物获得的药物涂料，其重量比为DEAEMA:MMA，范围为35:65至55:45，其中 共聚物用C3-C10-二羧酸部分中和。

公开(公告)号：US20230257501A1

公开(公告)日：2023-08-17

申请号：US18014508

申请日：2021-07-02

Applicant: BASF SE

Inventor： Theo Smit ,  Ferdinand Paul Brandl ,  Felicitas Guth ,  Karl Kolter ,  Frank Schmidt

IPC: C08F226/10 ,  C08F2/06 ,  A61K9/16

CPC classification number: C08F226/10 ,  C08F2/06 ,  A61K9/1635

Abstract: Copolymer, wherein structural units are derived from: i) an acrylic carboxylic acid monomer (4 to 18% by weight), selected from the group consisting of acrylic acid and methacrylic acid, ii) a 5 hydrophobic methacrylate (more than 8% by weight), selected from a group consisting of isopropyl methacrylate, tert-butyl methacrylate and cyclohexyl methacrylate, iii) a N-vinyl lactam, selected from a group consisting of N-vinyl pyrrolidone and N-vinylcaprolactam and optionally iv) 2-hydroxyethyl methacrylate, with the proviso that the total amount of structural units derived from the monomer groups adds up to 100% by weight, and the calculated solubility parameter SP of 10 the copolymer is between 22.0 and 25.0 MPa1/2, and the use of the copolymers as crystallization inhibitors in pharmaceutical dosage forms for inhibiting the recrystallization of an active ingredient in an aqueous environment of a human or animal body.

公开(公告)号：US11491090B2

公开(公告)日：2022-11-08

申请号：US16339404

申请日：2017-10-04

Applicant: BASF SE

Inventor： Ewelina Burakowska-Meise ,  Wolfgang Krause ,  Patrick Leibach ,  Karl Kolter

IPC: A61K8/11 ,  A61K9/50 ,  C08L67/03 ,  A61Q5/02 ,  A61Q13/00 ,  A61K8/85 ,  A61Q19/10 ,  C11D3/50 ,  B01J13/06 ,  B01J13/20 ,  B01J13/02 ,  A61K8/06 ,  A61K8/81 ,  A61K8/87 ,  A61K9/00

Abstract: The present invention relates to compositions of spherical microparticles composed of a wall material and at least one cavity that comprises a gas and/or a liquid, which have pores on the surface thereof, wherein the spherical microparticles have a mean particle diameter of 10-600 μm and wherein at least 80% of those microparticles, the particle diameter of which does not deviate from the mean particle diameter of the microparticles of the composition by more than 20%, each have on average at least 10 pores, the diameter of which is in the range from 1/5000 to ⅕ of the mean particle diameter, and, furthermore, the diameter of each of these pores is at least 20 nm,
wherein the wall material consists of a composition comprising at least one aliphatic-aromatic polyester, and the wall material has a solubility at 25° C. of at least 50 g/l in dichloromethane, a method for the preparation thereof and also the use thereof.

公开(公告)号：US11154508B2

公开(公告)日：2021-10-26

申请号：US16624332

申请日：2018-06-05

Applicant: BASF SE

Inventor： Bernhard Fussnegger ,  Silke Gebert ,  Felicitas Guth ,  Karl Kolter

IPC: A61K9/20 ,  A61K9/08

Abstract: A finely divided binder in powder form consisting of a polyethylene glycol-polyvinyl alcohol graft polymer particles, wherein the particles have an average particle size D[4,3] in the range of from 10 to 70 μm.

公开(公告)号：US20210163879A1

公开(公告)日：2021-06-03

申请号：US16772865

申请日：2018-12-07

Applicant: BASF SE

Inventor： Felicitas Guth ,  Karl Kolter ,  Nigel A. Langley ,  Kerri Gaumer Freidl ,  Kristina Brueggemann

IPC: C12N5/00

Abstract: A method for stabilizing cells in cell culture production, the method comprising culturing a cell line capable of expressing proteins in cell culture media, and supplementing said cell culture media with a graft polymer in which N-vinyl caprolactam and vinyl acetate moieties are grafted on a polyethylene glycol backbone.