公开(公告)号：US20150087509A1

公开(公告)日：2015-03-26

申请号：US14398239

申请日：2013-04-29

Applicant: BASF SE

Inventor： Karsten Körber ,  Florian Kaiser ,  Gemma Veitch ,  Wolfgang Von Deyn ,  Nina Gertrud Bandur ,  Joachim Dickhaut ,  Arun Narine ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

IPC: C07D403/04 ,  A01N43/56 ,  A61K45/06 ,  A61K31/506 ,  A01N47/34 ,  C07D403/14 ,  C07F9/6558 ,  A01N57/24 ,  A61K31/675 ,  C07D405/14 ,  C07D409/14

CPC classification number: C07D403/04 ,  A01N43/56 ,  A01N47/34 ,  A01N47/36 ,  A01N57/24 ,  A01N57/32 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07F9/247 ,  C07F9/65583

Abstract: The present invention relates to substituted pyrazole-containing compounds of formula (I), and the stereoisomers and salts thereof, wherein the substituents are as defined in the description.The present invention further relates to a method for combating or controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites, to a process for the preparation of a composition for treating infested or infected animals and/or for protecting animals against infestation or infection by parasites, and to a compound according to the invention for use as a medicament.

Abstract translation: 本发明涉及式（I）的取代的含吡唑化合物及其立体异构体和盐，其中取代基如说明书中所定义。 本发明还涉及一种防治无脊椎害虫的方法，一种用于保护植物繁殖材料和/或从其生长的植物的方法，包括至少一种根据本发明的化合物的植物繁殖材料的方法， 用于治疗或保护动物免受寄生虫感染或感染，涉及制备用于治疗感染或感染动物的组合物和/或用于保护动物免受寄生虫感染或感染的方法，以及根据本发明的化合物 用作药物。

公开(公告)号：US09556141B2

公开(公告)日：2017-01-31

申请号：US14359446

申请日：2012-11-20

Applicant: BASF SE

Inventor： Maximilian Dochnahl ,  Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch

IPC: C07D401/14 ,  C07D471/10 ,  C07D401/04

CPC classification number: C07D401/04 ,  C07D471/10

Abstract: The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined in the description and the claims, with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a carbonylation by reacting it with a reagent selected from the group consisting carbon dioxide or a carbon dioxide equivalent, to obtain a compound of formula (I-A); and it relates to further conversions to yield a N-substituted 1H-pyrazole-5-carbonyl chloride compound of the formula (I)

Abstract translation: 本发明涉及制备式（IA）的N-取代的1H-吡唑-5-羧酸酯化合物的方法，包括以下步骤：i）将式（II）的化合物去质子化，其中变量R1，R2和 r各自如说明书和权利要求中所定义，其中镁 - 有机碱具有碳结合的镁; 和ii）通过使步骤（i）中获得的产物与选自二氧化碳或二氧化碳当量的试剂反应来进行羰基化，得到式（I-A）化合物; 并且涉及进一步转化得到式（I）的N-取代的1H-吡唑-5-碳酰氯化合物，

公开(公告)号：US20150087843A1

公开(公告)日：2015-03-26

申请号：US14359446

申请日：2012-11-20

Applicant: BASF SE

Inventor： Maximilian Dochnahl ,  Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D471/10

Abstract: The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined in the description and the claims, with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a carbonylation by reacting it with a reagent selected from the group consisting carbon dioxide or a carbon dioxide equivalent, to obtain a compound of formula (I-A); and it relates to further conversions to yield a N-substituted 1H-pyrazole-5-carbonyl chloride compound of the formula (I)

Abstract translation: 本发明涉及制备式（IA）的N-取代的1H-吡唑-5-羧酸酯化合物的方法，包括以下步骤：i）将式（II）的化合物去质子化，其中变量R1，R2和 r各自如说明书和权利要求中所定义，其中镁 - 有机碱具有碳结合的镁; 和ii）通过使步骤（i）中获得的产物与选自二氧化碳或二氧化碳当量的试剂反应来进行羰基化，得到式（I-A）化合物; 并且涉及进一步转化得到式（I）的N-取代的1H-吡唑-5-碳酰氯化合物，

公开(公告)号：US09174967B2

公开(公告)日：2015-11-03

申请号：US14398239

申请日：2013-04-29

Applicant: BASF SE

Inventor： Karsten Korber ,  Florian Kaiser ,  Gemma Veitch ,  Wolfgang Von Deyn ,  Nina Gertrud Bandur ,  Joachim Dickhaut ,  Arun Narine ,  Deborah L. Culbertson ,  Paul Neese ,  Koshi Gunjima

IPC: C07D403/04 ,  C07D403/14 ,  A01N43/56 ,  A01N47/36 ,  A01N57/32 ,  C07F9/24 ,  A01N47/34 ,  A01N57/24 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14 ,  C07F9/6558

CPC classification number: C07D403/04 ,  A01N43/56 ,  A01N47/34 ,  A01N47/36 ,  A01N57/24 ,  A01N57/32 ,  A61K31/506 ,  A61K31/675 ,  A61K45/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07F9/247 ,  C07F9/65583

Abstract: The present invention relates to substituted pyrazole-containing compounds of formula (I), and the stereoisomers and salts thereof, wherein the substituents are as defined in the description. The present invention further relates to a method for combating or controlling invertebrate pests, to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material comprising at least one compound according to the present invention, to a method for treating or protecting an animal from infestation or infection by parasites, to a process for the preparation of a composition for treating infested or infected animals and/or for protecting animals against infestation or infection by parasites, and to a compound according to the invention for use as a medicament.