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公开(公告)号：US11510990B2
公开(公告)日：2022-11-29
申请号：US17485424
申请日：2021-09-26
发明人： Xinle Wu , Haixia Zou , Yuanyuan Zhang , Bo Wu , Wei Guo
IPC分类号： A61K47/60 , C07K14/50 , C07K14/605
摘要： The present disclosure provides conjugates of polypeptides comprising GLP-1, polypeptide linker and FGF21. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
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公开(公告)号：US11453711B2
公开(公告)日：2022-09-27
申请号：US17467288
申请日：2021-09-06
发明人： Yuanyuan Zhang , Haixia Zou , Xinyu Zhao , Yaoguang Jin , Xu Chen , Peng Zhai , Wei Guo
IPC分类号： C07K14/605 , C07K14/475 , A61K38/00 , A61K47/64
摘要： The present disclosure provides fusion polypeptides comprising GLP-1 and GDF15, the polypeptide complexes, and the conjugates thereof. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
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公开(公告)号：US11884711B2
公开(公告)日：2024-01-30
申请号：US17935134
申请日：2022-09-26
发明人： Yuanyuan Zhang , Wei Guo , Xinyu Zhao , Haixia Zou , Yaoguang Jin , Xu Chen , Peng Zhai
IPC分类号： C07K14/495 , A61P3/04 , C07K16/18 , A61K38/00 , A61K39/00
CPC分类号： C07K14/495 , A61P3/04 , C07K16/18 , A61K38/00 , A61K2039/505 , C07K2317/24 , C07K2317/569 , C07K2317/92 , C07K2319/31
摘要： The present disclosure provides fusion polypeptides comprising serum albumin binding single domain antibody and GDF15, the polypeptide complexes thereof. Pharmaceutical compositions comprising the same and methods of treating diseases are also provided.
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公开(公告)号：US11529394B2
公开(公告)日：2022-12-20
申请号：US17562014
申请日：2021-12-27
发明人： Yuanyuan Zhang , Xinle Wu , Haixia Zou , Peng Zhai , Yaoguang Jin , Bo Wu , Xu Chen , Wei Guo , Xinyu Zhao , Zuobin Wang , Lingli Zeng
摘要： The present disclosure provides a polypeptide conjugates comprising GLP-1 receptor agonist and a peptide linker, and pharmaceutical compositions comprising the same. Methods of using such for treating diseases are also provided.
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