公开(公告)号：US20240327544A1

公开(公告)日：2024-10-03

申请号：US18579086

申请日：2022-07-13

Applicant: BIONTECH SE ,  GENMAB A/S

Inventor： Ugur SAHIN ,  Alexander MUIK ,  Sina FELLERMEIER-KOPF ,  Yali FU ,  Homer ADAMS, III ,  Gaurav BAJAJ ,  Brandon HIGGS ,  Mark FERESHTEH ,  Vanessa SPIRES ,  Jordan BLUM ,  Patricia GARRIDO CASTRO ,  Michelle NIEWOOD ,  Friederike GIESEKE ,  Karsten BECKMANN ,  Claudia PAULMANN ,  Ivan KUZMANOV ,  Esther Cornelia Wilhelmina BREIJ ,  Lars GUELEN ,  Jost NEIJSSEN ,  Bart-Jan DE KREUK ,  Richard HIBBERT ,  Janine SCHUURMAN ,  Aran Frank LABRIJN

IPC: C07K16/46 ,  A61K39/00

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/71 ,  C07K2317/76

Abstract: The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.