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公开(公告)号：US20230295335A1
公开(公告)日：2023-09-21
申请号：US18184120
申请日：2023-03-15
Applicant: Genmab A/S , BioNTech SE
Inventor： Andreea IOAN , Esther Cornelia Wilhelmina BREIJ , Lars GUELEN , David P.E. SATIJN , Ugur SAHIN , Alexander MUIK , Kristina SCHÖDEL , Sina FELLERMEIER-KOPF , Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran Frank LABRIJN
CPC classification number: C07K16/30 , C07K16/2878 , C07K2317/31 , C07K2317/92
Abstract: The present invention provides a binding agent that binds to EpCAM and to CD137 which is useful to treat or prevent a tumor or cancer, or to prevent progression of a tumor or cancer.
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公开(公告)号：US20240327544A1
公开(公告)日：2024-10-03
申请号：US18579086
申请日：2022-07-13
Applicant: BIONTECH SE , GENMAB A/S
Inventor： Ugur SAHIN , Alexander MUIK , Sina FELLERMEIER-KOPF , Yali FU , Homer ADAMS, III , Gaurav BAJAJ , Brandon HIGGS , Mark FERESHTEH , Vanessa SPIRES , Jordan BLUM , Patricia GARRIDO CASTRO , Michelle NIEWOOD , Friederike GIESEKE , Karsten BECKMANN , Claudia PAULMANN , Ivan KUZMANOV , Esther Cornelia Wilhelmina BREIJ , Lars GUELEN , Jost NEIJSSEN , Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran Frank LABRIJN
CPC classification number: C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/76
Abstract: The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.
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3.发明公开公开(公告)号：US20230365693A1
公开(公告)日：2023-11-16
申请号：US18315686
申请日：2023-05-11
Applicant: BioNTech SE , Genmab A/S
Inventor： Ugur SAHIN , Sina FELLERMEIER-KOPF , Friederike GIESEKE , Karsten BECKMANN , Claudia PAULMANN , Alexander MUIK , Ivan KUZMANOV , Esther Cornelia Wilhelmina BREIJ , Patricia GARRIDO CASTRO , Jordan BLUM , Lars GUELEN , Joost NEIJSSEN , Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran Frank LABRIJN
IPC: C07K16/28
CPC classification number: C07K16/2818 , C07K2317/24 , C07K2317/92
Abstract: The present disclosure relates to antibodies having the ability to bind to the immune checkpoint protein programmed death-1 (PD-1), such as human PD-1, or nucleic acids encoding such antibodies, wherein the antibodies comprise modifications in the Fc region eliminating or reducing a Fc-mediated effector function of the antibodies. The present disclosure also relates to compositions or kits comprising said antibodies or nucleic acids, as well as to the use of these antibodies or nucleic acids or compositions in the field of medicine, preferably in the field of immunotherapy, e.g., for the treatment of cancers. The present invention further relates to methods for inducing an immune response in a subject comprising providing to the subject an antibody of the present disclosure or one or more nucleic acids encoding such an antibody, or a composition comprising said antibody or nucleic acids.
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公开(公告)号：US20250066506A1
公开(公告)日：2025-02-27
申请号：US18596319
申请日：2024-03-05
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Patrick VAN BERKEL , Kristin STRUMANE , Aran Frank LABRIJN , Joost J. NEIJSSEN , Joyce I. MEESTERS , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
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公开(公告)号：US20220169738A1
公开(公告)日：2022-06-02
申请号：US17369542
申请日：2021-07-07
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD , Jan VAN DE WINKEL , David SATIJN , Paul PARREN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Edward N. VAN DEN BRINK
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20170369594A1
公开(公告)日：2017-12-28
申请号：US15599395
申请日：2017-05-18
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Joyce I. MEESTERS , Bart DE GOEIJ , Aran Frank LABRIJN , Paul PARREN , Janine SCHUURMAN
Abstract: Bispecific antibodies which comprise one antigen-binding region binding to an epitope of human epidermal growth factor receptor 2 (HER2) and one antigen-binding region binding to human CD3, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods for preparing and using the antibodies are also disclosed.
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公开(公告)号：US20230322947A1
公开(公告)日：2023-10-12
申请号：US17950350
申请日：2022-09-22
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Joost J. NEIJSSEN , Edward Norbert VAN DEN BRINK , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/40 , C07K16/2863 , C07K16/2887 , C07K16/2896 , C07K16/1063 , C07K16/36 , C07K16/00 , C07K16/2809 , C07K16/32 , C07K16/1271 , C07K2317/51 , C07K2317/515 , C07K2317/53 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/92 , C07K2317/41 , C07K2317/74 , C07K2317/732 , C07K2317/734 , C07K2317/24 , C07K2317/71 , A61K2039/505
Abstract: Described herein are, proteins comprising amino acid substitutions in at least one of a first and a second polypeptide chain. Furthermore, is described the uses and methods related to said proteins.
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公开(公告)号：US20170320962A1
公开(公告)日：2017-11-09
申请号：US15491378
申请日：2017-04-19
Applicant: GENMAB A/S
Inventor： Joost J. NEIJSSEN , Bart DE GOEIJ , Edward Norbert VAN DEN BRINK , Aran Frank LABRIJN , Rene HOET , Janine SCHUURMAN , Paul PARREN , Jan VAN DE WINKEL
IPC: C07K16/30 , A61K45/06 , C07K16/40 , A61K39/395 , G01N33/574 , C07K16/28 , A61K39/00
Abstract: Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US20170233497A1
公开(公告)日：2017-08-17
申请号：US15414122
申请日：2017-01-24
Applicant: GENMAB A/S
Inventor： Aran Frank LABRIJN , Joyce I. MEESTERS , Ewald T. J. VAN DEN BREMER , Joost J. NEIJSSEN , Patrick VAN BERKEL , Bart DE GOEIJ , Tom VINK , Jan VAN DE WINKEL , Janine SCHUURMAN , Paul PARREN
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/1063 , C07K16/2809 , C07K16/2863 , C07K16/2887 , C07K16/32 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/6854
Abstract: Novel heterodimeric antibody-Fc-containing proteins, such as bispecific antibodies, and novel methods for producing such proteins
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10.发明申请TRANSGENIC ANIMALS PRODUCING MONOVALENT HUMAN ANTIBODIES AND ANTIBODIES OBTAINABLE FROM THESE ANIMALS 审中-公开生产从这些动物获得的单一人类抗体和抗体的转基因动物公开(公告)号：US20170037138A1
公开(公告)日：2017-02-09
申请号：US15072983
申请日：2016-03-17
Applicant: GENMAB A/S
Inventor： Janine SCHUURMAN , Tom VINK , Jan VAN DE WINKEL , Aran Frank LABRIJN , Paul PARREN , Willem Karel BLEEKER , Frank BEURSKENS , Patrick VAN BERKEL
IPC: C07K16/28
CPC classification number: C07K16/2887 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/732 , C07K2317/77 , C07K2317/90 , C12N15/8509 , C12N2740/16011
Abstract: The invention relates to novel non-human transgenic animals, which upon antigenic stimulation are capable of producing monovalent antibodies binding to a selected antigen, modified heavy chain transgenes, methods for producing the non-human transgenic animals, methods for immunizing the non-human transgenic animals for as well as monovalent antibodies obtainable by such immunization methods.
Abstract translation: 本发明涉及新型非人转基因动物，其在抗原刺激时能够产生结合选定抗原的单价抗体，修饰的重链转基因，用于产生非人转基因动物的方法，用于免疫非人转基因动物的方法 动物以及通过这种免疫方法可获得的单价抗体。
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