公开(公告)号：US20230089255A1

公开(公告)日：2023-03-23

申请号：US17786442

申请日：2020-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Susan WEE ,  Joseph L. BENC ,  Xinyu WANG ,  Upender VELAPARTHI ,  Louis S. CHUPAK ,  Chatan P. DARNE ,  Min DING ,  Robert G. GENTLES ,  Yazhong HUANG ,  Scott W. MARTIN ,  Ivar M. MCDONALD ,  Richard E. OLSON ,  Xiaofan ZHENG ,  John S. TOKARSKI ,  Bireshwar DASGUPTA ,  Manjunatha Narayana Rao KAMBLE ,  Raju MANNOORI ,  Haslbur RAHAMAN ,  Prasada Rao JALAGAM ,  Saumya ROY ,  Gopikishan TONUKUNURU ,  Sivasudar VELAIAH ,  Jayakumar Sankara WARRIER ,  Kotha Rathnakar REDDY ,  Thiruvenkadam RAJA ,  Denise GRUNENFELDER ,  Michael WICHROSKI

IPC: A61K31/519 ,  A61K31/496 ,  A61K39/395 ,  A61P35/00

Abstract: Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD 1/PD-L 1 axis and/or an antagonist of CTLA4.

公开(公告)号：US20180215761A1

公开(公告)日：2018-08-02

申请号：US15746597

申请日：2016-07-21

Applicant: Bristol-Myers Squibb Company

Inventor： Lalgudi S. HARIKRISHNAN ,  Brian E. FINK ,  Robert M. BORZILLERI ,  Gopikishan TONUKUNURU ,  Hasibur RAHAMAN ,  Jayakumar SANKARA WARRIER ,  Balaji SESHADRI

IPC: C07D487/04 ,  A61K31/541 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53 ,  A61K31/541

Abstract: The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβ R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.