公开(公告)号：US20230089255A1

公开(公告)日：2023-03-23

申请号：US17786442

申请日：2020-12-18

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Susan WEE ,  Joseph L. BENC ,  Xinyu WANG ,  Upender VELAPARTHI ,  Louis S. CHUPAK ,  Chatan P. DARNE ,  Min DING ,  Robert G. GENTLES ,  Yazhong HUANG ,  Scott W. MARTIN ,  Ivar M. MCDONALD ,  Richard E. OLSON ,  Xiaofan ZHENG ,  John S. TOKARSKI ,  Bireshwar DASGUPTA ,  Manjunatha Narayana Rao KAMBLE ,  Raju MANNOORI ,  Haslbur RAHAMAN ,  Prasada Rao JALAGAM ,  Saumya ROY ,  Gopikishan TONUKUNURU ,  Sivasudar VELAIAH ,  Jayakumar Sankara WARRIER ,  Kotha Rathnakar REDDY ,  Thiruvenkadam RAJA ,  Denise GRUNENFELDER ,  Michael WICHROSKI

IPC分类号： A61K31/519 ,  A61K31/496 ,  A61K39/395 ,  A61P35/00

摘要： Provided are inhibitors of diacylglycerol kinases (DGK) and methods for treating diseases that would benefit from the stimulation of the immune system, such as cancer and infections diseases, comprising administering a DGK inhibitor in combination with an antagonist of the PD 1/PD-L 1 axis and/or an antagonist of CTLA4.