公开(公告)号：US10308652B2

公开(公告)日：2019-06-04

申请号：US15558708

申请日：2016-03-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stephen T. Wrobleski ,  Gregory D. Brown ,  Shuqun Lin ,  Jingwu Duan ,  Zhonghui Lu ,  Murali T. G. Dhar ,  Hai-Yun Xiao ,  Andrew J. Tebben

IPC: C07D487/14 ,  C07D491/147 ,  A61K31/5025 ,  A61P37/00 ,  C07D471/14 ,  C07D487/06 ,  A61P29/00 ,  A61P27/00

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: —(CR3R3)2-5-, —(CR3R3)x-Y—(CR3R3)y-, —Y—(CR3R3)2-3-Y—, —CR3R3-Y—(CR3R3)2-Y—, —Y—(CR3R3)2-Y—CR3R3-; and Y, R1, R2, R3, R5, R6, R8, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US10189840B2

公开(公告)日：2019-01-29

申请号：US15558692

申请日：2016-03-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Hai-Yun Xiao ,  Murali T. G. Dhar ,  Jingwu Duan ,  Bin Jiang ,  Andrew J. Tebben

IPC: C07D471/14 ,  C07D487/06 ,  A61P37/00 ,  A61P29/00

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.