公开(公告)号：US09428511B2

公开(公告)日：2016-08-30

申请号：US14426625

申请日：2013-09-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bingwei Vera Yang ,  Gregory D. Brown ,  Arun Kumar Gupta ,  William J. Pitts

IPC: C07D487/04 ,  C07B59/00

CPC classification number: C07D487/04 ,  C07B59/002 ,  C07B2200/05

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎症和自身免疫性疾病。

公开(公告)号：US10308652B2

公开(公告)日：2019-06-04

申请号：US15558708

申请日：2016-03-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stephen T. Wrobleski ,  Gregory D. Brown ,  Shuqun Lin ,  Jingwu Duan ,  Zhonghui Lu ,  Murali T. G. Dhar ,  Hai-Yun Xiao ,  Andrew J. Tebben

IPC: C07D487/14 ,  C07D491/147 ,  A61K31/5025 ,  A61P37/00 ,  C07D471/14 ,  C07D487/06 ,  A61P29/00 ,  A61P27/00

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: —(CR3R3)2-5-, —(CR3R3)x-Y—(CR3R3)y-, —Y—(CR3R3)2-3-Y—, —CR3R3-Y—(CR3R3)2-Y—, —Y—(CR3R3)2-Y—CR3R3-; and Y, R1, R2, R3, R5, R6, R8, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20150210703A1

公开(公告)日：2015-07-30

申请号：US14426625

申请日：2013-09-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Bingwei Vera Yang ,  Gregory D. Brown ,  Arun Kumar Gupta ,  William J. Pitts

IPC: C07D487/04

CPC classification number: C07D487/04 ,  C07B59/002 ,  C07B2200/05

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式I化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎症和自身免疫性疾病。

公开(公告)号：US10301306B2

公开(公告)日：2019-05-28

申请号：US15527343

申请日：2015-12-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Amy C. Hart ,  William J. Pitts ,  Harold Mastalerz ,  Junqing Guo ,  Gregory D. Brown

IPC: C07D471/04

Abstract: Compounds having Formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK3 modulation. All the variables defined herein.