公开(公告)号：US10851108B2

公开(公告)日：2020-12-01

申请号：US16094288

申请日：2017-04-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Prashantha Gunaga ,  Jeremy Richter ,  Navnath Dnyanoba Yadav ,  Manoranjan Panda ,  Sreenivasulu Godesi

IPC: A61K31/519 ,  C07D487/04 ,  C07D471/04 ,  C07D271/04 ,  C07D407/04 ,  C07D407/06 ,  C07D413/14 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

公开(公告)号：US20190127380A1

公开(公告)日：2019-05-02

申请号：US16094288

申请日：2017-04-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Prashantha Gunaga ,  Jeremy Richter ,  Navnath Dnyanoba Yadav ,  Manoranjan Panda ,  Sreenivasulu Godesi

IPC: C07D487/04 ,  C07D407/04 ,  C07D471/04 ,  C07D407/06 ,  C07D413/14 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.