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公开(公告)号：US20230124468A1
公开(公告)日：2023-04-20
申请号：US17960199
申请日：2022-10-05
发明人： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20220324836A1
公开(公告)日：2022-10-13
申请号：US17231088
申请日：2021-04-15
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US10723723B2
公开(公告)日：2020-07-28
申请号：US16344823
申请日：2017-11-02
发明人： Prashantha Gunaga , Rajeev S. Bhide , Rajesh Onkardas Bora , Manoranjan Panda , Navnath Dnyanoba Yadav , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , A61P13/02 , A61P9/00 , A61P9/12 , A61P9/04 , C07D471/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20230322726A1
公开(公告)日：2023-10-12
申请号：US18125826
申请日：2023-03-24
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
CPC分类号： C07D401/14 , A61K31/517 , A61K31/549 , A61K31/5377 , A61K45/06 , C07D239/94 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： A compound of formula I
wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.-
公开(公告)号：US20200339550A1
公开(公告)日：2020-10-29
申请号：US16928079
申请日：2020-07-14
发明人： Navnath Dnyanoba Yadav , Rajeev S. Bhide , Rajesh Onkardas Bora , Prashantha Gunaga , Manoranjan Panda , Eldon Scott Priestley , Jeremy Richter
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is: each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20190127380A1
公开(公告)日：2019-05-02
申请号：US16094288
申请日：2017-04-19
发明人： Prashantha Gunaga , Jeremy Richter , Navnath Dnyanoba Yadav , Manoranjan Panda , Sreenivasulu Godesi
IPC分类号： C07D487/04 , C07D407/04 , C07D471/04 , C07D407/06 , C07D413/14 , C07D519/00
摘要： Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US20140303168A1
公开(公告)日：2014-10-09
申请号：US14200063
申请日：2014-03-07
发明人： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Pothukanuri Srinivasu
IPC分类号： C07D405/14 , C07D403/04 , C07D401/04 , A61K31/506 , C07D401/14 , A61K31/502
CPC分类号： C07D405/14 , A61K31/502 , A61K31/506 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04
摘要： A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
摘要翻译： 其中A，R1，R3和R24的式（I）化合物在此描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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公开(公告)号：US11008306B2
公开(公告)日：2021-05-18
申请号：US16864825
申请日：2020-05-01
发明人： James A. Johnson , John Lloyd , Heather Finlay , James Neels , Naveen Kumar Dhondi , Prashantha Gunaga , Abhisek Banerjee , Ashokkumar Adisechan
IPC分类号： C07D401/14 , C07D239/95 , C07D401/12 , C07D403/04 , C07D403/12 , C07D407/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/517 , A61K31/5377 , A61K31/549 , A61K45/06 , C07D239/94 , C07D405/12 , C07D471/04 , C07D513/04
摘要： A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
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公开(公告)号：US10851108B2
公开(公告)日：2020-12-01
申请号：US16094288
申请日：2017-04-19
发明人： Prashantha Gunaga , Jeremy Richter , Navnath Dnyanoba Yadav , Manoranjan Panda , Sreenivasulu Godesi
IPC分类号： A61K31/519 , C07D487/04 , C07D471/04 , C07D271/04 , C07D407/04 , C07D407/06 , C07D413/14 , C07D519/00
摘要： Disclosed are compounds of Formula (I), or a salt thereof, wherein: X is CR4 or N; Y is CR4 or N, provided that Y is N only if X is N; R1 is Formulae (A) or (B); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, R3, R4, L1, R1a, R1b, R1c, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
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公开(公告)号：US09403834B2
公开(公告)日：2016-08-02
申请号：US14772403
申请日：2014-03-10
发明人： Heather Finlay , Ashok Kumar Adisechan , Prashantha Gunaga , John Lloyd , Srinivasu Pothukanuri
IPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14 , A61K31/53 , A61P9/06 , A61P9/04
CPC分类号： C07D487/04 , A61K31/53 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D413/04 , C07D413/14
摘要： A compound of formula (I), wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
摘要翻译： 式（I）化合物，其中A，R 1，R 3和R 24在本文中描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。
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