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公开(公告)号：US10787498B2
公开(公告)日：2020-09-29
申请号：US14766036
申请日：2014-02-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Aaron P Yamniuk , Stanley R Krystek
IPC: C07K14/435 , C07K14/78
Abstract: Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target.
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