公开(公告)号：US20130056442A1

公开(公告)日：2013-03-07

申请号：US13639823

申请日：2011-04-29

申请人： Bing Li ,  Xiaogang Li ,  Zhehui Wang

发明人： Bing Li ,  Xiaogang Li ,  Zhehui Wang

IPC分类号： B05D5/06 ,  B44C1/22 ,  B05D3/10

CPC分类号： G02B6/136 ,  G02B6/1228 ,  G02B2006/12097

摘要： The present invention relates to a method of manufacturing optical waveguide devices. The order of patterning/etch in the method is first a deeper etching then shallow etching. In some embodiments, the first etching forms a mesa and the second etching removes a portion of material that comprises the mesa. In addition, there can be a planarization step. The deeper trenches are desirably conducive to filling. The method may use a cross-lithography method to reduce alignment errors between multiple patterning/etching steps. The method may use an oxidation and stripping off process to smooth a surface of the waveguide and/or reduce an initial dimension of the waveguide.

摘要翻译： 本发明涉及一种制造光波导器件的方法。 在该方法中图案化/蚀刻的顺序首先是较深的蚀刻，然后进行浅蚀刻。 在一些实施例中，第一蚀刻形成台面并且第二蚀刻去除包括台面的材料的一部分。 另外，可以进行平面化步骤。 较深的沟槽理想地有利于填充。 该方法可以使用交叉光刻方法来减少多个图案化/蚀刻步骤之间的对准误差。 该方法可以使用氧化和剥离工艺来平滑波导的表面和/或减小波导的初始尺寸。

公开(公告)号：US20080269123A1

公开(公告)日：2008-10-30

申请号：US11906600

申请日：2007-10-02

申请人： Rong Li ,  Xiaogang Li

发明人： Rong Li ,  Xiaogang Li

IPC分类号： A61K38/16 ,  G01N33/53 ,  A61P13/12

CPC分类号： C07K14/4702 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention is directed to methods of treating or ameliorating an effect of a polycystic disease. More particularly, the methods include administering to a patient in need thereof an amount of a modulator of a tumor necrosis factor (TNF) pathway, which is sufficient to treat or ameliorate an effect of a polycystic disease. Methods of treating or ameliorating an effect of a polycystic kidney disease (PKD) are also provided. Methods are also provided for identifying a candidate compound that may be effective to treat or ameliorate an effect of a polycystic disease or to increase polycystin-2 (PC2) function or decrease Rab11-Family of Interacting Protein2 (FIP2) function. Further provided are methods for identifying a patient having, or who is at risk for developing, a polycystic disease or who would benefit from treatment with a TNF-alpha inhibitor.

摘要翻译： 本发明涉及治疗或改善多囊性疾病的作用的方法。 更具体地，所述方法包括向有需要的患者施用一定量的肿瘤坏死因子（TNF）途径的调节剂，其足以治疗或改善多囊性疾病的作用。 还提供了治疗或改善多囊肾病（PKD）的作用的方法。 还提供了用于鉴定可能有效治疗或改善多囊性疾病的作用或增加多囊卵巢蛋白-2（PC2）功能或减少Rab11-家族的交互蛋白2（FIP2）功能的候选化合物的方法。 进一步提供的是用于鉴定具有或有风险发展为多囊性疾病或可受益于用TNF-α抑制剂治疗的患者的患者的方法。

公开(公告)号：US20080035615A1

公开(公告)日：2008-02-14

申请号：US11226834

申请日：2005-09-14

申请人： Xiaogang Li ,  W.H. Scott Lawson ,  Y. Norman Zhou

发明人： Xiaogang Li ,  W.H. Scott Lawson ,  Y. Norman Zhou

IPC分类号： B23K26/24

CPC分类号： B23K26/244 ,  B23K26/211 ,  B23K26/32 ,  B23K2101/34 ,  B23K2103/04 ,  B23K2103/08 ,  B23K2103/50

摘要： Techniques are described for lap welding steel articles with a corrosion resistant coating. First and second steel members with a coating comprising zinc are welded together in a lap region. A metal selected to have a melting temperature below the boiling temperature of zinc, and to form a liquid alloy with the zinc, which alloy has a boiling temperature above the melting temperature of steel, is added to the lap region.

摘要翻译： 描述了用于搭接具有耐腐蚀涂层的钢制品的技术。 具有包含锌的涂层的第一和第二钢构件在搭接区域焊接在一起。 选择熔融温度低于锌的沸点的金属，并且与该锌合金的沸点温度高于钢的熔融温度的锌形成液态合金。

公开(公告)号：US08007790B2

公开(公告)日：2011-08-30

申请号：US11906600

申请日：2007-10-02

申请人： Rong Li ,  Xiaogang Li

发明人： Rong Li ,  Xiaogang Li

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K38/00 ,  C07K16/24

CPC分类号： C07K14/4702 ,  C12N15/113 ,  C12N2310/14

摘要： The present invention is directed to methods of treating or ameliorating an effect of a polycystic disease. More particularly, the methods include administering to a patient in need thereof an amount of a modulator of a tumor necrosis factor (TNF) pathway, which is sufficient to treat or ameliorate an effect of a polycystic disease. Methods of treating or ameliorating an effect of a polycystic kidney disease (PKD) are also provided. Methods are also provided for identifying a candidate compound that may be effective to treat or ameliorate an effect of a polycystic disease or to increase polycystin-2 (PC2) function or decrease Rab11-Family of Interacting Protein2 (FIP2) function. Further provided are methods for identifying a patient having, or who is at risk for developing, a polycystic disease or who would benefit from treatment with a TNF-alpha inhibitor.

摘要翻译： 本发明涉及治疗或改善多囊性疾病的作用的方法。 更具体地，所述方法包括向有需要的患者施用一定量的肿瘤坏死因子（TNF）途径的调节剂，其足以治疗或改善多囊性疾病的作用。 还提供了治疗或改善多囊肾病（PKD）的作用的方法。 还提供了用于鉴定可能有效治疗或改善多囊性疾病的作用或增加多囊卵巢蛋白-2（PC2）功能或减少Rab11-家族的交互蛋白2（FIP2）功能的候选化合物的方法。 进一步提供的是用于鉴定具有或有风险发展为多囊性疾病或可受益于用TNF-α抑制剂治疗的患者的患者的方法。

公开(公告)号：US20080207711A1

公开(公告)日：2008-08-28

申请号：US12072740

申请日：2008-02-28

申请人： Rong Li ,  Xiaogang Li

发明人： Rong Li ,  Xiaogang Li

IPC分类号： A61K31/425

CPC分类号： A61K31/425

摘要： Described herein is a method of treating an ID2-related disorder comprising administering to a patient in need thereof an ID2 inhibitor or derivative thereof.

摘要翻译： 本文描述了治疗ID2相关病症的方法，包括向有需要的患者施用ID2抑制剂或其衍生物。