公开(公告)号：US20230414516A1

公开(公告)日：2023-12-28

申请号：US18036676

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra ,  Serguei A. Tchessalov ,  Steffen Panzner ,  Christian Reinsch ,  Kaushik Thanki ,  Sukrut Somani

IPC: A61K9/19 ,  A61K9/16 ,  A61K9/51 ,  A61K31/7105

CPC classification number: A61K9/19 ,  A61K9/1694 ,  A61K9/1623 ,  A61K9/5123 ,  A61K31/7105

Abstract: This invention relates to enhanced stabilization and improved lyophilization methods of pharmaceutical substances.

公开(公告)号：US20240041785A1

公开(公告)日：2024-02-08

申请号：US18036679

申请日：2021-11-14

Applicant: BioNTech SE

Inventor： Steffen Panzner ,  Christian Reinsch ,  Kaushik Thanki ,  Sukrut Somani ,  Serguei A. Tchessalov ,  Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra

IPC: A61K9/51 ,  A61K47/24 ,  A61K47/18 ,  A61K47/28 ,  A61K47/26 ,  A61K39/215

CPC classification number: A61K9/5123 ,  A61K47/24 ,  A61K47/18 ,  A61K47/28 ,  A61K9/5146 ,  A61K47/26 ,  A61K9/5192 ,  A61K39/215 ,  A61K2039/6018

Abstract: The present disclosure provides technologies relating to stabilization of lipid nanoparticle mRNA compositions (e.g., vaccines).

公开(公告)号：US20230414747A1

公开(公告)日：2023-12-28

申请号：US18036677

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Steffen Panzner ,  Ugur Sahin ,  Jorrit-Jan Krijger ,  Kaushik Thanki ,  Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra ,  Serguei A. Tchessalov

IPC: A61K39/215 ,  A61K9/51 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61P31/14 ,  C12N2770/20034 ,  A61K2039/53

Abstract: The present disclosure relates generally to the field of lipid nanoparticle (LNP) compositions comprising RNA, methods for preparing and storing such compositions, and the use of such compositions in therapy.