公开(公告)号：US20240041785A1

公开(公告)日：2024-02-08

申请号：US18036679

申请日：2021-11-14

Applicant: BioNTech SE

Inventor： Steffen Panzner ,  Christian Reinsch ,  Kaushik Thanki ,  Sukrut Somani ,  Serguei A. Tchessalov ,  Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra

IPC: A61K9/51 ,  A61K47/24 ,  A61K47/18 ,  A61K47/28 ,  A61K47/26 ,  A61K39/215

CPC classification number: A61K9/5123 ,  A61K47/24 ,  A61K47/18 ,  A61K47/28 ,  A61K9/5146 ,  A61K47/26 ,  A61K9/5192 ,  A61K39/215 ,  A61K2039/6018

Abstract: The present disclosure provides technologies relating to stabilization of lipid nanoparticle mRNA compositions (e.g., vaccines).

公开(公告)号：US20230201817A1

公开(公告)日：2023-06-29

申请号：US18085206

申请日：2022-12-20

Applicant: BioNTech Delivery Technologies GmbH ,  BioNTech SE

Inventor： Christian Reinsch ,  David Estapé Izquierdo ,  Sierk Poetting ,  Ugur Sahin ,  Alexander Muik ,  Asaf Poran ,  Martin Lang ,  Oliver Hennig ,  Karsten Pietron-Kattmann ,  Manfred Brunen ,  Rainer Kröner ,  Mario Büttner ,  Sven Stegmann ,  Kristin Hoffmann

IPC: B01L1/00 ,  G16B30/00 ,  G16B50/30 ,  G16B20/20 ,  A61K39/215 ,  B01F25/25 ,  B01D61/14

CPC classification number: B01L1/52 ,  A61K39/215 ,  B01D61/145 ,  B01D61/147 ,  B01D61/149 ,  B01F25/25 ,  G16B20/20 ,  G16B30/00 ,  G16B50/30 ,  A61K2039/53

Abstract: A portable system for producing a formulation comprising lipid nanoparticle (LNP)-encapsulated RNA includes: a first sub-system comprising multiple drug substance formulation modules, the first sub-system comprising: a transcription module for forming an RNA solution via in vitro transcription; and a second sub-system operatively downstream of the first sub-system comprising multiple drug product formation modules, the second sub-system comprising: an LNP formulation module for producing a first RNA-LNP preparation from the RNA solution, wherein each of the transcription module and the LNP formulation module is contained within a separate standard shipping container.

公开(公告)号：US20230414516A1

公开(公告)日：2023-12-28

申请号：US18036676

申请日：2021-11-15

Applicant: BioNTech SE

Inventor： Bakul Subodh Bhatnagar ,  Ramin Darvari ,  Sumit Luthra ,  Serguei A. Tchessalov ,  Steffen Panzner ,  Christian Reinsch ,  Kaushik Thanki ,  Sukrut Somani

IPC: A61K9/19 ,  A61K9/16 ,  A61K9/51 ,  A61K31/7105

CPC classification number: A61K9/19 ,  A61K9/1694 ,  A61K9/1623 ,  A61K9/5123 ,  A61K31/7105

Abstract: This invention relates to enhanced stabilization and improved lyophilization methods of pharmaceutical substances.