公开(公告)号：US20200270335A1

公开(公告)日：2020-08-27

申请号：US16063423

申请日：2016-12-16

Applicant: Biogen MA Inc.

Inventor： R. Blake Pepinsky ,  Richelle Sopko ,  Joshua Mugford ,  Andreas Lehmann ,  Joseph W. Arndt ,  Nels E. Pederson ,  Brenda K. Minesinger

IPC: C07K16/18 ,  A61K47/65 ,  C07K14/765

Abstract: Proteins containing a DKK2 polypeptide or a fragment or variant thereof are described. These proteins contain human serum albumin sequences and/or include substitutions in the DKK2 polypeptide that decrease heparin binding. These proteins are useful in the treatment of disorders such as acute kidney injury and fibrosis.