公开(公告)号：US20220089704A1

公开(公告)日：2022-03-24

申请号：US17288445

申请日：2019-10-28

Applicant: Biogen MA Inc. ,  National Research Council of Canada

Inventor： Benjamin A. Smith ,  Andreas Lehmann ,  Thomas O. Cameron ,  R. Blake Pepinsky ,  Dingyi Wen ,  Graham K. Farrington ,  Gopalan Raghunathan ,  Nels E. Pederson ,  Danica Stanimirovic ,  Traian Sulea ,  Arsalan S. Haqqani

IPC: C07K16/18 ,  A61P25/28 ,  C07K16/28 ,  C07K14/47

Abstract: Featured are compositions comprising humanized and engineered variants of an antibody variable domain (e.g., FC5), chimeric molecules comprising same, compositions comprising same, and uses thereof.

公开(公告)号：US20200270335A1

公开(公告)日：2020-08-27

申请号：US16063423

申请日：2016-12-16

Applicant: Biogen MA Inc.

Inventor： R. Blake Pepinsky ,  Richelle Sopko ,  Joshua Mugford ,  Andreas Lehmann ,  Joseph W. Arndt ,  Nels E. Pederson ,  Brenda K. Minesinger

IPC: C07K16/18 ,  A61K47/65 ,  C07K14/765

Abstract: Proteins containing a DKK2 polypeptide or a fragment or variant thereof are described. These proteins contain human serum albumin sequences and/or include substitutions in the DKK2 polypeptide that decrease heparin binding. These proteins are useful in the treatment of disorders such as acute kidney injury and fibrosis.

公开(公告)号：US20220348623A1

公开(公告)日：2022-11-03

申请号：US17541765

申请日：2021-12-03

Applicant: Biogen MA Inc.

Inventor： R. Blake Pepinsky ,  Andreas Lehmann ,  Dingyi Wen

IPC: C07K14/51 ,  C12P21/02

Abstract: Methods of activating GDF11 proteins in vitro as well as formulations of mature GDF11 polypeptides with enhanced solubility at neutral pH are provided.

公开(公告)号：US20200031895A1

公开(公告)日：2020-01-30

申请号：US16468347

申请日：2017-12-15

Applicant: Biogen MA Inc.

Inventor： R. Blake Pepinsky ,  Andreas Lehmann ,  Dingyi Wen

IPC: C07K14/51 ,  C12P21/02

Abstract: Methods of activating GDF11 proteins in vitro as well as formulations of mature GDF11 polypeptides with enhanced solubility at neutral pH are provided.