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1.发明申请Novel Mixed Ligand Core/Shell Iron Oxide Nanoparticles for Inflammation Imaging 审中-公开新型混合配体核/壳氧化铁纳米粒子用于炎症成像公开(公告)号：US20090226376A1
公开(公告)日：2009-09-10
申请号：US12042701
申请日：2008-03-05
IPC分类号： A61K49/18
CPC分类号： A61K49/1836 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： A nanostructure includes (1) an inorganic nanoparticle core; (2) a first ligand, having a first chain length, bonded to the inorganic nanoparticle core; the first ligand having a charge; and (3) a second ligand, having a second chain length, bonded to the inorganic nanoparticle core; the second ligand is hydrophilic. The second chain length is longer than the first chain length such that varying a mole percent quantity of the first ligand does not substantially alter a hydrodynamic diameter of the nanostructure. Methods for making these nanostructures and their use in magnetic resonance imaging and management of inflammatory conditions are provided.
摘要翻译： 纳米结构包括（1）无机纳米颗粒核; （2）具有第一链长度的第一配体键合到无机纳米颗粒核心上; 第一配体具有电荷; 和（3）具有第二链长度的第二配体键合到无机纳米颗粒核心上; 第二配体是亲水的。 第二链长比第一链长长，使得改变第一配体的摩尔百分比量基本上不改变纳米结构的流体动力学直径。 提供了制备这些纳米结构的方法及其在磁共振成像和炎症状态管理中的应用。
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2.发明申请NOVEL PEI-PEG GRAFT COPOLYMER COATING OF IRON OXIDE NANOPARTICLES FOR INFLAMMATION IMAGING 审中-公开用于荧光成像的氧化乙烯纳米粒子的新型PEI-PEG共聚物涂层公开(公告)号：US20090280063A1
公开(公告)日：2009-11-12
申请号：US12117873
申请日：2008-05-09
CPC分类号： A61K49/186 , A61K49/1839 , A61K49/1857
摘要： A nanostructure includes a nanoparticle core (110) and a ligand (120) bonded to the nanoparticle core (110). The ligand includes a linking group (130) having a first end bonded to a polyethylene imine (PEI) polymer (140) and a second end bonded to the nanoparticle core (110) and a polyethylene glycol (PEG) polymer (150) grafted to the PEI polymer (140). Methods for making these nanostructures and their use in magnetic resonance imaging and management of inflammatory conditions are provided.
摘要翻译： 纳米结构包括纳米颗粒核心（110）和与纳米颗粒核心（110）结合的配体（120）。 配体包括具有与聚乙烯亚胺（PEI）聚合物（140）结合的第一末端和与纳米颗粒核心（110）结合的第二末端的连接基团（130）和接枝到聚乙二醇（PEG）聚合物 PEI聚合物（140）。 提供了制备这些纳米结构的方法及其在磁共振成像和炎症状态管理中的应用。
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3.发明申请NON-RADIOACTIVE TRACEABLE METAL ISOTOPE-ENRICHED NANOPARTICLES AND METHOD OF THEIR USE FOR DETERMINING BIODISTRIBUTION 失效非放射性可追踪金属同位异构化纳米粒子及其用于确定生物分布的方法公开(公告)号：US20090246143A1
公开(公告)日：2009-10-01
申请号：US12057650
申请日：2008-03-28
申请人： Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Andrew Soliz Torres , Ying Zhou , Chiaki Treynor , Daniel Eugene Meyer
发明人： Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Andrew Soliz Torres , Ying Zhou , Chiaki Treynor , Daniel Eugene Meyer
CPC分类号： A61K49/1848 , B82Y5/00 , B82Y15/00 , G01N2458/15 , Y10T428/2991 , Y10T428/2993
摘要： Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.
摘要翻译： 提供了非放射性可溯源金属同位素富集纳米颗粒的组成及其用于确定体内生物分布的方法。 所述方法包括以下步骤：（a）将纳米颗粒引入生物材料中，其中所述纳米颗粒包含至少一种无机核，所述无机核包含至少两种预定比例的金属同位素; 其中至少一种金属同位素是富集的非放射性可追溯金属同位素，和（b）基于金属同位素的预定比例确定生物材料中纳米颗粒的分布。
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公开(公告)号：US20070098642A1
公开(公告)日：2007-05-03
申请号：US11265729
申请日：2005-11-02
申请人： Peter Bonitatebus , Oskar Axelsson , Amit Kulkarni , Brian Bales , Deborah Walter , Andrew Torres , Chiaki Treynor
发明人： Peter Bonitatebus , Oskar Axelsson , Amit Kulkarni , Brian Bales , Deborah Walter , Andrew Torres , Chiaki Treynor
IPC分类号： A61K49/04
CPC分类号： C09C1/00 , A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01P2004/04 , C01P2004/64 , C09C1/24 , C09C3/08 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.
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5.发明申请公开(公告)号：US20070098640A1
公开(公告)日：2007-05-03
申请号：US11265686
申请日：2005-11-02
申请人： Peter Bonitatebus , Oskar Axelsson , Amit Kulkarni , Brian Bales , Deborah Walter , Andrew Torres , Chiaki Treynor
发明人： Peter Bonitatebus , Oskar Axelsson , Amit Kulkarni , Brian Bales , Deborah Walter , Andrew Torres , Chiaki Treynor
IPC分类号： A61K49/04
CPC分类号： C09C1/00 , A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01P2004/04 , C01P2004/64 , C09C1/24 , C09C3/08 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.
摘要翻译： 本发明通常涉及核/壳纳米颗粒，其中这种核/壳纳米颗粒包含纳米颗粒核和纳米壳，该纳米壳围绕纳米颗粒核设置，使得在聚集体中，它们形成核/壳纳米颗粒，其可操作地用作 X射线/计算机断层摄影（CT）中的成像剂。 通常，这种基于核/壳纳米颗粒的X射线CT成像剂还包含用于将成像剂靶向患病部位的靶向物种。
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6.发明授权Non-radioactive traceable metal isotope-enriched nanoparticles and method of their use for determining biodistribution 失效非放射性可追溯金属同位素富集纳米颗粒及其用于确定生物分布的方法公开(公告)号：US08246932B2
公开(公告)日：2012-08-21
申请号：US12057650
申请日：2008-03-28
申请人： Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Andrew Soliz Torres , Ying Zhou , Chiaki Treynor , Daniel Eugene Meyer
发明人： Peter John Bonitatibus, Jr. , Amit Mohan Kulkarni , Andrew Soliz Torres , Ying Zhou , Chiaki Treynor , Daniel Eugene Meyer
IPC分类号： A61B5/055
CPC分类号： A61K49/1848 , B82Y5/00 , B82Y15/00 , G01N2458/15 , Y10T428/2991 , Y10T428/2993
摘要： Composition of non-radioactive traceable metal isotope-enriched nanoparticles, and methods of their use for determining in-vivo biodistribution are provided. The methods comprise the steps of: (a) introducing the nanoparticles into the biological material, wherein the nanoparticles comprise at least one inorganic core, and the inorganic core comprises at least two metal isotopes in a predetermined ratio; wherein at least one metal isotope is enriched non-radioactive traceable metal isotope and (b) determining the distribution of the nanoparticles in the biological material based on the predetermined ratio of the metal isotopes.
摘要翻译： 提供了非放射性可溯源金属同位素富集纳米颗粒的组成及其用于确定体内生物分布的方法。 所述方法包括以下步骤：（a）将纳米颗粒引入生物材料中，其中所述纳米颗粒包含至少一种无机核，所述无机核包含至少两种预定比例的金属同位素; 其中至少一种金属同位素是富集的非放射性可追溯金属同位素，和（b）基于金属同位素的预定比例确定生物材料中纳米颗粒的分布。
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公开(公告)号：US20070098641A1
公开(公告)日：2007-05-03
申请号：US11265728
申请日：2005-11-02
申请人： Peter Bonitatebus , Oskar Axelsson , Amit Kulkarni , Brian Bales , Deborah Walter , Andrew Torres , Chiaki Treynor
发明人： Peter Bonitatebus , Oskar Axelsson , Amit Kulkarni , Brian Bales , Deborah Walter , Andrew Torres , Chiaki Treynor
IPC分类号： A61K49/04
CPC分类号： C09C1/00 , A61K49/0423 , B82Y5/00 , B82Y30/00 , C01G27/02 , C01P2004/04 , C01P2004/64 , C09C1/24 , C09C3/08 , C09C3/12
摘要： The present invention is generally directed to core/shell nanoparticles, wherein such core/shell nanoparticles comprise a nanoparticle core and a nanoshell disposed about the nanoparticle core such that, in the aggregate, they form a core/shell nanoparticle that is operable for use as an imaging agent in X-ray/computed tomography (CT). Typically, such core/shell nanoparticle-based X-ray CT imaging agents further comprise a targeting species for targeting the imaging agent to diseased sites.
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