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10 条记录 (耗时 0.04 秒)

    Nanoparticles with inorganic core and methods of using them
    7.
    发明申请
    Nanoparticles with inorganic core and methods of using them 审中-公开
    具有无机核的纳米颗粒及其使用方法

    公开(公告)号：US20060018835A1

    公开(公告)日：2006-01-26

    申请号：US10818235

    申请日：2004-04-02

    申请人： Patrick Lucien Malenfant ,  Havva Acar ,  Peter Bonitatebus ,  William Dixon ,  Amit Kulkarni

    发明人： Patrick Lucien Malenfant ,  Havva Acar ,  Peter Bonitatebus ,  William Dixon ,  Amit Kulkarni

    IPC分类号： A61K49/18 ,  A61K9/16 ,  A61K9/50

    CPC分类号： A61K49/1848 ,  A61K49/186 ,  B82Y5/00

    摘要： An aspect of the invention includes a nanoparticle including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating includes of at least coating structure I, II, or III wherein the nanoparticle is substantially non-agglomerated and has diameter in a range from about 1 nm to about 100 nm. An aspect of the invention also encompasses a method of making a substantially non-agglomerated nanoparticle having a diameter in a range from about 1 nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III. An aspect of the invention also encompasses various methods of using the substantially non-agglomerated nanoparticle having a diameter in a range from about 1 nm to about 100 nm including a substantially monodisperse inorganic core with a surface and a coating substantially covering the surface of the substantially monodisperse inorganic core, wherein the coating comprises coating structure I, II, or III.

    摘要翻译： 本发明的一个方面包括纳米颗粒，其包括具有表面的基本上单分散的无机核，涂层基本覆盖基本上单分散的无机核的表面，其中该涂层至少包括涂层结构I，II或III，其中纳米颗粒是 基本上非聚集并且具有在约1nm至约100nm范围内的直径。 本发明的一个方面还包括制备直径在约1nm至约100nm范围内的基本上非团聚的纳米颗粒的方法，包括基本上单分散的无机芯，其表面和涂层基本上覆盖基本上 单分散无机芯，其中涂层包括涂层结构I，II或III。 本发明的一个方面还包括使用直径在约1nm至约100nm范围内的基本上未附聚的纳米颗粒的各种方法，包括基本上单分散的无机芯，其表面和基本覆盖基本上表面的涂层 单分散无机芯，其中涂层包括涂层结构I，II或III。

    Contrast agents for magnetic resonance imaging
    8.
    发明申请
    Contrast agents for magnetic resonance imaging 审中-公开
    磁共振成像对比剂

    公开(公告)号：US20050260137A1

    公开(公告)日：2005-11-24

    申请号：US10889618

    申请日：2004-07-12

    申请人： Havva Acar ,  Faisal Syud ,  Rachel Garaas ,  Peter Bonitatebus ,  Amit Kulkarni

    发明人： Havva Acar ,  Faisal Syud ,  Rachel Garaas ,  Peter Bonitatebus ,  Amit Kulkarni

    IPC分类号： A61K49/00 ,  A61K49/18

    CPC分类号： B82Y5/00 ,  A61K49/1839 ,  A61K49/186

    摘要： A contrast agent for magnetic resonance imaging having a plurality of nanoparticles. Each of the nanoparticles has: a signal generating core having a diameter of up to 10 nm; at least one organic layer of at least one of a polymer, a monomer, and a surfactant; and a water soluble outer shell of at least one of a polymer, a monomer, and a ligand. The organic layer is adsorbed upon and substantially surrounds and stabilizes the signal generating core. The water soluble outer shell solubilizes and provides biocompatibility for each of the nanoparticles. The contrast agents provide enhanced relaxivity, high signal-to-noise ratios, and targeting abilities. In addition, the contrast agents possess resistance to agglomeration, controlled particle size, blood clearance rate, and biodistribution. Methods of making such contrast agents and nanoparticles are also disclosed.

    摘要翻译： 一种用于具有多个纳米颗粒的磁共振成像的造影剂。 每个纳米颗粒具有：具有高达10nm的直径的信号产生芯; 聚合物，单体和表面活性剂中的至少一种的至少一种有机层; 以及聚合物，单体和配体中的至少一种的水溶性外壳。 有机层被吸附在基本上并且基本上包围和稳定信号产生芯。 水溶性外壳增溶并提供每种纳米颗粒的生物相容性。 造影剂提供增强的松弛度，高信噪比和靶向能力。 此外，造影剂具有抗凝集，受控粒度，血清清除率和生物分布。 还公开了制备这种造影剂和纳米颗粒的方法。

    Method of making crystalline nanoparticles
    10.
    发明申请
    Method of making crystalline nanoparticles 审中-公开
    制造结晶纳米粒子的方法

    公开(公告)号：US20060088659A1

    公开(公告)日：2006-04-27

    申请号：US11036935

    申请日：2005-01-18

    申请人： Peter Bonitatebus ,  Havva Acar

    发明人： Peter Bonitatebus ,  Havva Acar

    IPC分类号： B05D7/00

    CPC分类号： B82Y30/00 ,  B82Y25/00 ,  C01G49/0072 ,  C01G49/02 ,  C01G49/06 ,  C01G49/08 ,  C01G51/00 ,  C01P2002/32 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/52 ,  C01P2004/64 ,  C09C1/22 ,  C09C1/24 ,  C09C3/08 ,  H01F1/0054 ,  H01F1/0063 ,  H01F1/37

    摘要： A method of forming a plurality of monodisperse nanoparticles. Each of the nanoparticles comprises a nanocrystalline inorganic core and at least one outer coating comprising an ionizable stabilizing material that substantially covers the core. The method comprises the steps of: combining a nonpolar aprotic organic solvent, an oxidant, and a first surfactant; providing at least one organometallic compound to the combined nonpolar aprotic organic solvent, oxidant, and first surfactant; and heating the combined nonpolar aprotic organic solvent, oxidant, first surfactant, and the at least one organometallic compound under an inert gas atmosphere to a first temperature in a range from about 30° C. to about 400° C. for a first time interval, thereby reacting the at least one organometallic compound and the oxidant in the presence of the first surfactant and the nonpolar aprotic organic solvent to form a plurality of nanoparticles, each of the plurality of nanoparticles comprising a nanocrystalline inorganic core and at least one outer coating comprising the first surfactant. The at least one organometallic compound comprises a metal and at least one ligand.

    摘要翻译： 一种形成多个单分散纳米粒子的方法。 每个纳米颗粒包含纳米晶体无机核和至少一个包含基本覆盖芯的可离子化稳定材料的外涂层。 该方法包括以下步骤：将非极性非质子有机溶剂，氧化剂和第一表面活性剂组合; 向组合的非极性非质子有机溶剂，氧化剂和第一表面活性剂提供至少一种有机金属化合物; 以及在惰性气体气氛下将组合的非极性非质子有机溶剂，氧化剂，第一表面活性剂和至少一种有机金属化合物加热至约30℃至约400℃的第一温度，持续第一时间间隔 从而在第一表面活性剂和非极性非质子有机溶剂的存在下使至少一种有机金属化合物和氧化剂反应以形成多种纳米颗粒，所述多种纳米颗粒中的每一种包含纳米晶体无机核和至少一种外涂层，其包含 第一种表面活性剂。 所述至少一种有机金属化合物包含金属和至少一种配体。