公开(公告)号：US20230173142A1

公开(公告)日：2023-06-08

申请号：US18061997

申请日：2022-12-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Julia A. KORNFIELD ,  Benjamin J. LACCETTI ,  Dennis L. KO

IPC: A61L27/54

CPC classification number: A61L27/54 ,  A61L2300/406 ,  A61L2300/414

Abstract: Methods and systems and related devices particles and compositions are described for controlled ballistic delivery of particles to a target region of a multilayered tissue, the method comprising



determining a velocity vo,j of the set of substantially spherical particles by iterating vo,i=√{square root over (Ya/ρp)}((1/k)(d*/Dm)(μam-1)(√{square root over (Yaρp)})1-m(ρa/ρp))1/ni from i=0 to j, where n0=0.826 and ni=n0−q(v0,i-1√{square root over (ρa/Ya)}), until |(v0,i−v0,i-1)/vo,i-1|

公开(公告)号：US20220015943A1

公开(公告)日：2022-01-20

申请号：US17376024

申请日：2021-07-14

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Benjamin J. LACCETTI ,  Julia A. KORNFIELD

IPC: A61F9/00 ,  A61M5/30 ,  C08L67/04

Abstract: Methods and systems and related particles and compositions that can be used to deliver a biologically active cargo such as a drug to a cornea of an individual, the delivery performed in a rapid, nonsurgical, and/or controllable fashion are described. Particularly, a method is described for controlled ballistic delivery of a cargo in a microparticle to the cornea of an individual, including a biologically active cargo.