公开(公告)号：US20230173142A1

公开(公告)日：2023-06-08

申请号：US18061997

申请日：2022-12-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Julia A. KORNFIELD ,  Benjamin J. LACCETTI ,  Dennis L. KO

IPC: A61L27/54

CPC classification number: A61L27/54 ,  A61L2300/406 ,  A61L2300/414

Abstract: Methods and systems and related devices particles and compositions are described for controlled ballistic delivery of particles to a target region of a multilayered tissue, the method comprising



determining a velocity vo,j of the set of substantially spherical particles by iterating vo,i=√{square root over (Ya/ρp)}((1/k)(d*/Dm)(μam-1)(√{square root over (Yaρp)})1-m(ρa/ρp))1/ni from i=0 to j, where n0=0.826 and ni=n0−q(v0,i-1√{square root over (ρa/Ya)}), until |(v0,i−v0,i-1)/vo,i-1|