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公开(公告)号:US20230173142A1
公开(公告)日:2023-06-08
申请号:US18061997
申请日:2022-12-05
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor: Julia A. KORNFIELD , Benjamin J. LACCETTI , Dennis L. KO
IPC: A61L27/54
CPC classification number: A61L27/54 , A61L2300/406 , A61L2300/414
Abstract: Methods and systems and related devices particles and compositions are described for controlled ballistic delivery of particles to a target region of a multilayered tissue, the method comprising
determining a velocity vo,j of the set of substantially spherical particles by iterating vo,i=√{square root over (Ya/ρp)}((1/k)(d*/Dm)(μam-1)(√{square root over (Yaρp)})1-m(ρa/ρp))1/ni from i=0 to j, where n0=0.826 and ni=n0−q(v0,i-1√{square root over (ρa/Ya)}), until |(v0,i−v0,i-1)/vo,i-1|