公开(公告)号：US09201062B2

公开(公告)日：2015-12-01

申请号：US14334453

申请日：2014-07-17

Applicant: CELLOMICS, INC.

Inventor： Suk Jin Hong ,  Richik Niloy Ghosh

IPC: G06K9/00 ,  G01N33/50 ,  G06T7/00 ,  G06F19/00

CPC classification number: G01N33/5014 ,  G01N33/5067 ,  G01N2500/10 ,  G06F19/704 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.

Abstract translation: 预测化合物细胞毒性的方法包括：置于多个容器内的成像细胞，以获得成像的细胞靶标，每个容器用不同浓度的化合物处理，使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量值，以确定化合物的毒性。

公开(公告)号：US20140329717A1

公开(公告)日：2014-11-06

申请号：US14334453

申请日：2014-07-17

Applicant: CELLOMICS, INC.

Inventor： Suk Jin Hong ,  Richik Niloy Ghosh

IPC: G01N33/50 ,  G06T7/00

CPC classification number: G01N33/5014 ,  G01N33/5067 ,  G01N2500/10 ,  G06F19/704 ,  G06K9/00127 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.

Abstract translation: 预测化合物细胞毒性的方法包括：置于多个容器内的成像细胞，以获得成像的细胞靶标，每个容器用不同浓度的化合物处理，使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量值，以确定化合物的毒性。