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公开(公告)号：US20190154652A1
公开(公告)日：2019-05-23
申请号：US16259072
申请日：2019-01-28
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G01N2201/0631 , G01N2201/064 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US20150323462A1
公开(公告)日：2015-11-12
申请号：US14709239
申请日：2015-05-11
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N21/64 , G01N33/487 , G02B5/02
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
Abstract translation: 对生物样品进行成像和使用发色团分析成像样品的系统和方法。 发色团分析可以自己完成，也可以与高分辨率成像系统中的荧光团分析相结合。 为了进行发色团分析，可以用不同的发色团标记生物样品，并使用至少部分被发色团吸收的透射光成像。 为了进行荧光团分析，样品也可以用被激发光激发的荧光团标记。 发色团分析和荧光团分析可以使用高分辨率成像系统单独或同时进行。 该系统通过用不同波长的透射光照射发色团标记的样品并自动检测表示样品对着色光的差分吸收的图像来提供扩展的能力。
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公开(公告)号：US10234445B2
公开(公告)日：2019-03-19
申请号：US15594978
申请日：2017-05-15
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N33/487 , G01N21/64 , G02B5/02 , G01N21/25 , G01N21/31 , G01N35/00 , G02B21/16 , G02B21/36 , F21Y105/14 , F21Y105/10
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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Patent Agency Ranking
公开(公告)号：US20140329717A1
公开(公告)日：2014-11-06
申请号：US14334453
申请日：2014-07-17
Applicant: CELLOMICS, INC.
Inventor： Suk Jin Hong , Richik Niloy Ghosh
CPC classification number: G01N33/5014 , G01N33/5067 , G01N2500/10 , G06F19/704 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
Abstract: A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.
Abstract translation: 预测化合物细胞毒性的方法包括：置于多个容器内的成像细胞，以获得成像的细胞靶标，每个容器用不同浓度的化合物处理，使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量值，以确定化合物的毒性。
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公开(公告)号：US10393725B2
公开(公告)日：2019-08-27
申请号：US16259072
申请日：2019-01-28
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N33/487 , G01N21/64 , G02B5/02 , G01N21/31 , G01N21/25 , G02B21/36 , G02B21/16 , G01N35/00 , F21Y105/14 , F21Y105/10
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US20170248574A1
公开(公告)日：2017-08-31
申请号：US15594978
申请日：2017-05-15
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G01N2201/0631 , G01N2201/064 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US09683939B2
公开(公告)日：2017-06-20
申请号：US14709239
申请日：2015-05-11
Applicant: CELLOMICS, INC.
Inventor： Richik Niloy Ghosh , Dirk John VandenBerg, III , Keith Rao Heffley , Monica Jo Tomaszewski , Jeffrey Robert Haskins
IPC: G01N21/25 , G01N21/64 , G02B5/02 , G01N33/487 , F21Y105/00
CPC classification number: G01N33/487 , F21Y2105/10 , F21Y2105/14 , G01N21/253 , G01N21/255 , G01N21/31 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G01N21/6486 , G01N35/00029 , G01N2021/6439 , G01N2021/6491 , G01N2035/00158 , G01N2201/0627 , G02B5/0278 , G02B5/0294 , G02B21/16 , G02B21/367
Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
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公开(公告)号：US09201062B2
公开(公告)日：2015-12-01
申请号：US14334453
申请日：2014-07-17
Applicant: CELLOMICS, INC.
Inventor： Suk Jin Hong , Richik Niloy Ghosh
CPC classification number: G01N33/5014 , G01N33/5067 , G01N2500/10 , G06F19/704 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
Abstract: A method of predicting cell toxicity of a compound includes imaging cells positioned within a plurality of containers to obtain imaged cellular targets, each container being treated with a different concentration of the compound, the imaging being performed using a quantitative high-content cell imaging system; quantitatively measuring the imaged cellular targets to detect changes in multiple cellular targets associated with cytotoxicity of the compound; and analyzing measurements obtained from the measured imaged cellular targets over a range of compound concentrations to determine the toxicity of the compound.
Abstract translation: 预测化合物细胞毒性的方法包括：置于多个容器内的成像细胞，以获得成像的细胞靶标，每个容器用不同浓度的化合物处理，使用定量的高含量细胞成像系统进行成像; 定量测量成像的细胞靶标以检测与化合物的细胞毒性相关的多个细胞靶标的变化; 并且在化合物浓度的范围内分析从测量的成像细胞靶标获得的测量值，以确定化合物的毒性。
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